Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 2/20 | 0.39 |
| ▸ | PPARD | Q03181 | 2/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 4/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.37 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.37 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16952501 | 0.80 | ABCB1 (0.48) | HTR1AIDO1HCRTR1HCRTR2PDCD1 | |
| SCHEMBL20052962 | 0.76 | ALDH1A1 (0.43) | PTPN1PPARDALOX5PPARGHTR1A | |
| SCHEMBL21816474 | 0.75 | RPS6KA2 (0.40) | PTPN1PPARDALOX5PPARGHTR1A | |
| SCHEMBL2446603 | 0.74 | MEN1 (0.34) | PTPN1ADRA1APDCD1CD274MEN1 | |
| SCHEMBL17820 | 0.70 | IDO1 (0.57) | IDO1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL30829273 | 0.70 | IDO1 (0.57) | IDO1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL20052967 | 0.70 | HTR1A (0.37) | HTR1AMEN1KMT2AHTR2A | |
| SCHEMBL21231927 | 0.70 | HTR1A (0.39) | HTR1AADRA1AMEN1KMT2AALDH1A1 | |
| SCHEMBL1029593 | 0.70 | PDE4A (0.45) | ALOX5IDO1PDCD1CD274PDE4A | |
| SCHEMBL13486908 | 0.70 | MEN1 (0.49) | ALOX5IDO1PDCD1CD274PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9751830-B2 | Inhibitors of the tumor necrosis factor receptor complex | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2017-09-05 | — | — | US | disclosed |
| US-20150368187-A1 | INHIBITORS OF THE TUMOR NECROSIS FACTOR RECEPTOR COMPLEX | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2015-12-24 | — | — | US | disclosed |
| WO-2011115763-A1 | INHIBITORS OF THE TUMOR NECROSIS FACTOR RECEPTOR COMPLEX | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2011-09-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150368187-A1 | INHIBITORS OF THE TUMOR NECROSIS FACTOR RECEPTOR COMPLEX | TNFRSF1A, TNF, TNFRSF9 | PTPN1 1681/4885PPARD 3049/4885ALOX5 281/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.