Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 3/20 | 0.44 |
| ▸ | CETP | P11597 | 1/20 | 0.44 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.44 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16954472 | 0.88 | ALOX5 (0.45) | PDE4APDE4BPDE4CPDE4DIDO1 | |
| SCHEMBL505777 | 0.87 | CA1 (0.50) | PDE4APDE4BPDE4CPDE4DIDO1 | |
| SCHEMBL8135903 | 0.86 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DIDO1 | |
| SCHEMBL26046475 | 0.85 | PTGS2 (0.50) | IDO1LMNAKDM4EALDH1A1TP53 | |
| SCHEMBL27920540 | 0.85 | SLC6A2 (0.40) | IDO1PDCD1CD274KDM4EMAPK1 | |
| SCHEMBL4981005 | 0.82 | ALDH1A1 (0.48) | IDO1CETPKDM4EALDH1A1CYP3A4 | |
| SCHEMBL22560177 | 0.82 | PTGS2 (0.55) | PDCD1CD274LMNAKDM4EALDH1A1 | |
| SCHEMBL6300999 | 0.82 | HSP90AA1 (0.50) | CETPKDM4ETP53HPGDL3MBTL1 | |
| SCHEMBL6283334 | 0.81 | PTPN1 (0.40) | PDE4APDE4BPDE4CPDE4DIDO1 | |
| SCHEMBL12896559 | 0.81 | ALDH1A1 (0.42) | PDE4APDE4BPDE4CPDE4DIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8426440-B2 | Indolymaleimide derivatives | NOVARTIS AG (CH) | 2013-04-23 | — | — | US | disclosed |
| EP-2246346-B1 | Indolylmaleimide derivatives as protein kinase inhibitors | NOVARTIS AG (CH) | 2012-10-24 | — | — | EP | disclosed |
| EP-1904482-B1 | INDOLYLMALEIMIDE DERIVATIVES | NOVARTIS AG (CH) | 2011-01-19 | — | — | EP | disclosed |
| EP-2246346-A1 | Indolylmaleimide derivatives as protein kinase inhibitors | Novartis AG (CH) | 2010-11-03 | — | — | EP | disclosed |
| US-20100273774-A1 | INDOLYMALEIMIDE DERIVATIVES | WAGNER JUERGEN | 2010-10-28 | — | — | US | disclosed |
| US-7781438-B2 | Indolylmaleimide derivatives | NOVARTIS AG (CH) | 2010-08-24 | — | — | US | disclosed |
| US-20080318975-A1 | Indolylmaleimide Derivatives | NOVARTIS AG (CH) | 2008-12-25 | — | — | US | disclosed |
| EP-1362856-B1 | WATER-SOLUBLE TRIAZOLE FUNGICIDE | DAIICHI SANKYO CO LTD (JP) | 2008-09-10 | — | — | EP | disclosed |
| EP-1904482-A2 | INDOLYLMALEIMIDE DERIVATIVES | Novartis AG (CH) | 2008-04-02 | — | — | EP | disclosed |
| US-7230023-B2 | Water-soluble triazole fungicide | SANKYO COMPANY, LIMITED (JP) | 2007-06-12 | — | — | US | disclosed |
| EP-0103961-A1 | Allyloxy- and allylthio-2,3,4,5-tetrahydro-1H-3-benzazepines | SMITHKLINE BECKMAN CORPORATION (US) | 1984-03-28 | — | — | EP | disclosed |
| US-4247658-A | POROUS SURFACE LAYER | FIBER INDUSTRIES, INC. (US) | 1981-01-27 | — | — | US | disclosed |
| US-4240974-A | 1,2,3,4,9,9-HEXAHALO-1,4-DIHYDRO-1,4-METHANO-NAPHTHALENE-5,8 -DISULFONATE | LITTLE JULIAN R (US) | 1980-12-23 | — | — | US | disclosed |
| US-4174457-A | Carbamate | UNIROYAL, INC. (US) | 1979-11-13 | — | — | US | disclosed |
| US-4080375-A | SCALE INHIBITORS, CHELATING AGENTS | PETROLITE CORPORATION (US) | 1978-03-21 | — | — | US | disclosed |
| US-4080408-A | FIRE RETARDANTS | UNIROYAL, INC. (US) | 1978-03-21 | — | — | US | disclosed |
| US-4058568-A | FIRE RETARDANT | UNIROYAL, INC. (US) | 1977-11-15 | — | — | US | disclosed |
| US-4044189-A | TEXTILES, RUBBER REINFORCED WITH POLYESTER | FIBER INDUSTRIES, INC. (US) | 1977-08-23 | — | — | US | disclosed |
| US-4009200-A | FIREPROOFING POLYMERS | UNIROYAL, INC. (US) | 1977-02-22 | — | — | US | disclosed |
| US-4005020-A | OXYALKYLATED AMINES-FATTY ALCOHOLS-ALKYLPHENOLS, CELLOSOLVE; FOR PETROLEUM SYSTEMS | PETROLITE CORPORATION (US) | 1977-01-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100273774-A1 | INDOLYMALEIMIDE DERIVATIVES | IDO1, INMT, IDO2 | PDE4A 3578/4885PDE4B 3236/4885PDE4C 3903/4885 |
| US-20080318975-A1 | Indolylmaleimide Derivatives | IDH3A, INMT, IDH3B | PDE4A 3472/4885PDE4B 2723/4885PDE4C 3981/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.