Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.62 |
| ▸ | AXL | P30530 | 1/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.45 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | RAD52 | P43351 | 3/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.39 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.39 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.38 |
| ▸ | CDK2 | P24941 | 2/20 | 0.38 |
| ▸ | CDK9 | P50750 | 2/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.38 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.38 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2443328 | 0.87 | MAPK14 (0.81) | MAPK14AXLHIPK4SMN1; SMN2ALDH1A1 | |
| SCHEMBL31371552 | 0.87 | MAPK14 (0.81) | MAPK14AXLHIPK4SMN1; SMN2ALDH1A1 | |
| SCHEMBL4610007 | 0.85 | MAPK14 (0.46) | MAPK14AXLSCN9AHIPK4SMN1; SMN2 | |
| SCHEMBL2445182 | 0.82 | MAPK14 (0.73) | MAPK14AXLSCN9AHIPK4ALDH1A1 | |
| SCHEMBL3095955 | 0.81 | HIPK4 (0.49) | MAPK14AXLSCN9AHIPK4PTGER4 | |
| SCHEMBL2450395 | 0.80 | MAPK14 (0.49) | MAPK14AXLSMN1; SMN2ALDH1A1RAD52 | |
| SCHEMBL31371595 | 0.79 | MAPK14 (0.72) | MAPK14AXLALDH1A1RAD52UHRF1 | |
| SCHEMBL31371686 | 0.77 | MAPK14 (0.85) | MAPK14AXLSMN1; SMN2ALDH1A1RAD52 | |
| Arry-797 SCHEMBL31046796 | 0.77 | MAPK14 (1.00) | MAPK14SMN1; SMN2ALDH1A1RAD52CCNT1 | |
| Arry-797 SCHEMBL29349798 | 0.77 | MAPK14 (1.00) | MAPK14SMN1; SMN2ALDH1A1RAD52CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8017641-B2 | P38 inhibitors and methods of use thereof | ARRAY BIOPHARMA INC. (US) | 2011-09-13 | — | — | US | disclosed |