SCHEMBL24474374

SCHEMBL24474374

Cc1cccc(O)c1-n1c(=O)[nH]c(=O)c2cc(F)c(Cl)nc21

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK13 O15264 4/20 0.38
MAPK12 P53778 4/20 0.38
MAPK11 Q15759 4/20 0.38
MAPK14 Q16539 4/20 0.38
PARP1 P09874 5/20 0.36
KDM4E B2RXH2 2/20 0.36
CYP1A2 P05177 1/20 0.36
CYP2D6 P10635 1/20 0.36
CYP2C9 P11712 1/20 0.36
CYP2C19 P33261 1/20 0.36
KRAS P01116 4/20 0.35
DAO P14920 2/20 0.34
DDO Q99489 2/20 0.34
PDE7A Q13946 2/20 0.34
PDE4A P27815 1/20 0.33
PDE4B Q07343 1/20 0.33
PDE4C Q08493 1/20 0.33
PDE4D Q08499 1/20 0.33
PDE7B Q9NP56 1/20 0.33
TNKS O95271 6/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24474404 0.92 MAPK13 (0.42) MAPK13MAPK12MAPK11MAPK14PARP1
SCHEMBL29700616 0.92 MAPK13 (0.42) MAPK13MAPK12MAPK11MAPK14PARP1
SCHEMBL29700725 0.85 KRAS (0.38) MAPK13MAPK12MAPK11MAPK14KRAS
SCHEMBL21542783 0.85 KRAS (0.38) MAPK13MAPK12MAPK11MAPK14KRAS
SCHEMBL24474400 0.85 APLNR (0.39) MAPK13MAPK12MAPK11MAPK14PARP1
SCHEMBL24474197 0.84 BCAT1 (0.38) MAPK13MAPK12MAPK11MAPK14KDM4E
SCHEMBL29700674 0.84 KDM4E (0.35) MAPK13MAPK12MAPK11MAPK14PARP1
SCHEMBL24474375 0.83 KRAS (0.42) KRASPDE7APDE4APDE4BPDE4C
SCHEMBL24474245 0.83 HCAR1 (0.44) MAPK13MAPK12MAPK11MAPK14PARP1
SCHEMBL24474351 0.81 MAPK13 (0.34) MAPK13MAPK12MAPK11MAPK14KRAS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022111521-A1 AROMATIC COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF 杭州多域生物技术有限公司 2022-06-02 WO disclosed