Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Levocarnitine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | SLC22A16 | Q86VW1 | 1/20 | 0.40 |
| ▸ | ARG2 | P78540 | 4/20 | 0.40 |
| ▸ | NOS2 | P35228 | 4/20 | 0.39 |
| ▸ | NOS1 | P29475 | 3/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | GPR84 | Q9NQS5 | 4/20 | 0.37 |
| ▸ | ARG1 | P05089 | 3/20 | 0.37 |
| ▸ | NOS3 | P29474 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | BHMT | Q93088 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Carnitine SCHEMBL9128766 | 0.86 | GSR (0.59) | GSRMAPTSLC22A16ARG2NOS2 | |
| Carnitine SCHEMBL9901519 | 0.86 | GSR (0.59) | GSRMAPTSLC22A16ARG2NOS2 | |
| Levocarnitine SCHEMBL6553881 | 0.86 | GSR (0.59) | GSRMAPTSLC22A16ARG2NOS2 | |
| Carnitine SCHEMBL27486119 | 0.83 | SLC22A16 (0.59) | GSRMAPTSLC22A16ARG2NOS2 | |
| Carnitine SCHEMBL28276640 | 0.80 | SLC22A16 (0.51) | GSRMAPTSLC22A16ARG2NOS2 | |
| Lysine SCHEMBL27799649 | 0.78 | GSR (0.83) | GSRARG2NOS2NOS1BLM | |
| Lysine SCHEMBL27799650 | 0.78 | GSR (0.83) | GSRARG2NOS2NOS1BLM | |
| Lysine SCHEMBL18815986 | 0.78 | GSR (0.91) | GSRARG2NOS2NOS1BLM | |
| Lysine SCHEMBL27946776 | 0.77 | GSR (0.69) | GSRARG2NOS2NOS1BLM | |
| Lysine SCHEMBL16099029 | 0.77 | GSR (0.69) | GSRARG2NOS2NOS1BLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110229584-A1 | Compound for the control of herpes simplex virus using glycyrrhizic acid, lipoic acid, allantoin, and slippery elm | LIFESCAPE BIOSCIENCES | 2011-09-22 | — | — | US | claimed |