Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Carnitine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.59 |
| ▸ | SLC22A16 | Q86VW1 | 1/20 | 0.59 |
| ▸ | CPT2 | P23786 | 1/20 | 0.47 |
| ▸ | CPT1A | P50416 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ARG2 | P78540 | 4/20 | 0.39 |
| ▸ | ARG1 | P05089 | 3/20 | 0.39 |
| ▸ | NOS2 | P35228 | 5/20 | 0.39 |
| ▸ | NOS1 | P29475 | 4/20 | 0.39 |
| ▸ | NOS3 | P29474 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Levocarnitine SCHEMBL6553881 | 1.00 | GSR (0.59) | GSRSLC22A16CPT2CPT1AMAPT | |
| Carnitine SCHEMBL9128766 | 1.00 | GSR (0.59) | GSRSLC22A16CPT2CPT1AMAPT | |
| Carnitine SCHEMBL27486119 | 0.94 | SLC22A16 (0.59) | GSRSLC22A16CPT2CPT1AMAPT | |
| Carnitine SCHEMBL28276640 | 0.88 | SLC22A16 (0.51) | GSRSLC22A16CPT2CPT1AMAPT | |
| Levocarnitine SCHEMBL2447788 | 0.86 | GSR (0.56) | GSRSLC22A16MAPTARG2ARG1 | |
| Carnitine SCHEMBL27798506 | 0.84 | SLC22A16 (0.61) | GSRSLC22A16CPT2CPT1AMAPT | |
| Lysine SCHEMBL4622301 | 0.83 | GSR (0.65) | GSRCPT2CPT1AARG2ARG1 | |
| Lysine SCHEMBL273053 | 0.83 | GSR (0.65) | GSRCPT2CPT1AARG2ARG1 | |
| Levocarnitine SCHEMBL6635924 | 0.82 | SLC22A16 (0.59) | GSRSLC22A16CPT2CPT1AMAPT | |
| Carnitine SCHEMBL27492466 | 0.82 | SLC22A16 (0.59) | GSRSLC22A16CPT2CPT1AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110760449-B | Geotrichum galactose ZJPH1810 and application thereof in preparation of (S) -1- (2, 6-dichloro-3-fluorophenyl) ethanol | 浙江工业大学 | 2021-04-06 | — | — | CN | claimed |
| CN-110760449-A | Geotrichum galactose ZJPH1810 and application thereof in preparation of (S) -1- (2, 6-dichloro-3-fluorophenyl) ethanol | 浙江工业大学 | 2020-02-07 | — | — | CN | claimed |
| CN-113876946-B | Combined pharmaceutical application of PD-1 antibody and pseudomonas aeruginosa and pharmaceutical composition | 神威药业集团有限公司 | 2024-03-26 | — | — | CN | disclosed |
| WO-2023050694-A1 | COMBINED PHARMACEUTICAL USE OF PD-1 ANTIBODY AND PSEUDOMONAS AERUGINOSA AND PHARMACEUTICAL COMPOSITION THEREOF | 神威药业集团有限公司 | 2023-04-06 | — | — | WO | disclosed |
| CN-113876946-A | Combined pharmaceutical application and pharmaceutical composition of PD-1 antibody and pseudomonas aeruginosa | 神威药业集团有限公司 | 2022-01-04 | — | — | CN | disclosed |
| CN-112048538-B | Method for preparing (S) - [3, 5-bis (trifluoromethyl) phenyl ] ethanol by using Verticillium terrestris | 浙江工业大学 | 2021-12-21 | — | — | CN | disclosed |
| CN-110760449-B | Geotrichum galactose ZJPH1810 and application thereof in preparation of (S) -1- (2, 6-dichloro-3-fluorophenyl) ethanol | 浙江工业大学 | 2021-04-06 | — | — | CN | disclosed |
| CN-112048538-A | Method for preparing (S) - [3, 5-bis (trifluoromethyl) phenyl ] ethanol by using Verticillium terrestris | 浙江工业大学 | 2020-12-08 | — | — | CN | disclosed |
| CN-110760449-A | Geotrichum galactose ZJPH1810 and application thereof in preparation of (S) -1- (2, 6-dichloro-3-fluorophenyl) ethanol | 浙江工业大学 | 2020-02-07 | — | — | CN | disclosed |
| CN-103347521-B | Chemotherapy and the method for the metabolism target cancer cell of immunization therapy are used for treating cancer | 全球癌症治疗有限责任公司 | 2018-05-25 | — | — | CN | disclosed |
| US-20180117249-A1 | Warburg Effect Targeted Chemotherapy Apparatus | CURE CANCER WORLDWIDE LLC (US) | 2018-05-03 | — | — | US | disclosed |
| EP-2959291-A1 | METHODS OF DIAGNOSING AND TREATING CANCER BY DETECTING AND MANIPULATING MICROBES IN TUMORS | John Wayne Cancer Institute (US) | 2015-12-30 | — | — | EP | disclosed |
| US-20140271557-A1 | METHODS OF DIAGNOSING AND TREATING CANCER BY DETECTING AND MANIPULATING MICROBES IN TUMORS | LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE AT HARBOR-UCLA MEDICAL CENTER | 2014-09-18 | — | — | US | disclosed |
| WO-2014130162-A1 | METHODS OF DIAGNOSING AND TREATING CANCER BY DETECTING AND MANIPULATING MICROBES IN TUMORS | LEE DELPHINE J (US) | 2014-08-28 | — | — | WO | disclosed |
| US-20140056844-A1 | METHODS OF METABOLIC TARGETING CANCER CELLS USING CHEMO- AND IMMUNOTHERAPY FOR TREATING CANCER | CURE CANCER WORLDWIDE LLC | 2014-02-27 | — | — | US | disclosed |
| EP-2648734-A1 | METHODS OF METABOLIC TARGETING CANCER CELLS USING CHE MO- AND IMMUNOTHERAPY FOR TREATING CANCER | Cure Cancer Worldwide Corporation (US) | 2013-10-16 | — | — | EP | disclosed |
| CN-103347521-A | Methods of metabolic targeting cancer cells using che mo- and immunotherapy for treating cancer | CURE CANCER WORLDWIDE CORP | 2013-10-09 | — | — | CN | disclosed |
| WO-2012075679-A1 | METHODS OF METABOLIC TARGETING CANCER CELLS USING CHE MO- AND IMMUNOTHERAPY FOR TREATING CANCER | CURE CANCER WORLDWIDE CORPORATION (US) | 2012-06-14 | — | — | WO | disclosed |
| CN-1196672-C | Non-hydroscopic salts of active ingredients having therapeutical and/or nutritional activities and orally administrable compositions containing same | BIOSALTS SRL (IT) | 2005-04-13 | — | — | CN | disclosed |
| CN-1162397-C | Therapeutically and/or nutritionaly enhanced derivatives of active ingredients and orally administrable compsns. contg. same | �����ι�˾ | 2004-08-18 | — | — | CN | disclosed |