Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Levocarnitine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.59 |
| ▸ | SLC22A16 | Q86VW1 | 1/20 | 0.59 |
| ▸ | CPT2 | P23786 | 1/20 | 0.47 |
| ▸ | CPT1A | P50416 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ARG2 | P78540 | 4/20 | 0.39 |
| ▸ | ARG1 | P05089 | 3/20 | 0.39 |
| ▸ | NOS2 | P35228 | 5/20 | 0.39 |
| ▸ | NOS1 | P29475 | 4/20 | 0.39 |
| ▸ | NOS3 | P29474 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Carnitine SCHEMBL9901519 | 1.00 | GSR (0.59) | GSRSLC22A16CPT2CPT1AMAPT | |
| Carnitine SCHEMBL9128766 | 1.00 | GSR (0.59) | GSRSLC22A16CPT2CPT1AMAPT | |
| Carnitine SCHEMBL27486119 | 0.94 | SLC22A16 (0.59) | GSRSLC22A16CPT2CPT1AMAPT | |
| Carnitine SCHEMBL28276640 | 0.88 | SLC22A16 (0.51) | GSRSLC22A16CPT2CPT1AMAPT | |
| Levocarnitine SCHEMBL2447788 | 0.86 | GSR (0.56) | GSRSLC22A16MAPTARG2ARG1 | |
| Carnitine SCHEMBL27798506 | 0.84 | SLC22A16 (0.61) | GSRSLC22A16CPT2CPT1AMAPT | |
| Lysine SCHEMBL4622301 | 0.83 | GSR (0.65) | GSRCPT2CPT1AARG2ARG1 | |
| Lysine SCHEMBL273053 | 0.83 | GSR (0.65) | GSRCPT2CPT1AARG2ARG1 | |
| Levocarnitine SCHEMBL6635924 | 0.82 | SLC22A16 (0.59) | GSRSLC22A16CPT2CPT1AMAPT | |
| Carnitine SCHEMBL27492466 | 0.82 | SLC22A16 (0.59) | GSRSLC22A16CPT2CPT1AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1202956-B1 | THERAPEUTICALLY AND/OR NUTRITIONALLY ENHANCED DERIVATIVES OF ACTIVE INGREDIENTS AND ORALLY ADMINISTRABLE COMPOSITIONS CONTAINING SAME | SIGMA TAU IND FARMACEUTI (IT) | 2004-05-19 | — | — | EP | disclosed |
| US-6703042-B1 | STABLE, NON-HYGROSCOPIC; NUTRITIONAL SUPPLEMENTS | SIGMA-TAU INDUSTRIES FARMACEUTICHE RIUNITE S.P.A. (IT) | 2004-03-09 | — | — | US | disclosed |
| EP-1208078-B1 | NON-HYGROSCOPIC SALTS OF ACTIVE INGREDIENTS HAVING THERAPEUTICAL AND/OR NUTRITIONAL ACTIVITIES AND ORALLY ADMINISTRABLE COMPOSITIONS CONTAINING SAME | SIGMA TAU IND FARMACEUTI (IT) | 2004-02-18 | — | — | EP | disclosed |
| US-6653504-B1 | Salt of L-carnitine or alkanoyl L-carnitine with creatine or ornithine; dietetics | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2003-11-25 | — | — | US | disclosed |
| EP-0354848-B1 | PHARMACEUTICAL AND/OR DIETETICAL COMPOSITIONS CONTAINING L-CARNITINE AND L-LYSINE | Société anonyme dite: LABORATOIRE ROGER BELLON (FR) | 1992-11-11 | — | — | EP | disclosed |
| EP-0354848-A1 | Pharmaceutical and/or dietetical compositions containing L-carnitine and L-lysine | Société anonyme dite: LABORATOIRE ROGER BELLON (FR) | 1990-02-14 | — | — | EP | disclosed |