Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 8/20 | 0.73 |
| ▸ | WDR77 | Q9BQA1 | 7/20 | 0.73 |
| ▸ | AHCY | P23526 | 5/20 | 0.59 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.59 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.59 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.59 |
| ▸ | DPP4 | P27487 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.57 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.57 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.57 |
| ▸ | GAPDH | P04406 | 1/20 | 0.57 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.57 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.57 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.57 |
| ▸ | STAT6 | P42226 | 1/20 | 0.57 |
| ▸ | PI4KA | P42356 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24625909 | 0.89 | PRMT5 (0.77) | PRMT5WDR77AHCY | |
| SCHEMBL24626067 | 0.87 | PRMT5 (0.73) | PRMT5WDR77AHCY | |
| SCHEMBL31680251 | 0.86 | AHCY (0.68) | PRMT5WDR77AHCYHIF1ATMEM97 | |
| SCHEMBL397800 | 0.86 | AHCY (0.68) | PRMT5WDR77AHCYHIF1ATMEM97 | |
| SCHEMBL7803295 | 0.85 | AHCY (0.67) | PRMT5WDR77AHCYHIF1ATMEM97 | |
| SCHEMBL6671788 | 0.85 | AHCY (0.67) | PRMT5WDR77AHCYHIF1ATMEM97 | |
| SCHEMBL10599786 | 0.85 | ADORA1 (0.58) | PRMT5WDR77AHCYHIF1ATMEM97 | |
| SCHEMBL18009839 | 0.85 | PRMT5 (1.00) | PRMT5WDR77AHCY | |
| SCHEMBL21413928 | 0.85 | PRMT5 (1.00) | PRMT5WDR77AHCY | |
| SCHEMBL18039043 | 0.85 | PRMT5 (1.00) | PRMT5WDR77AHCY |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220168329-A1 | COMBINATORIAL DRUG TREATMENT OF CANCER | UNIVERSITY OF VIRGINIA | 2022-06-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220168329-A1 | COMBINATORIAL DRUG TREATMENT OF CANCER | DDIT3, PRMT3, PRMT1 | PRMT5 7/4885WDR77 146/4885AHCY 710/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.