Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 2/20 | 0.39 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | PLK4 | O00444 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | PRKCG | P05129 | 1/20 | 0.39 |
| ▸ | INSR | P06213 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | FES | P07332 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
| ▸ | ROS1 | P08922 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.39 |
| ▸ | FER | P16591 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | MARK3 | P27448 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21678542 | 0.79 | CDK2 (0.43) | AURKABRAFPLK4JAK2ROCK2 | |
| SCHEMBL22208416 | 0.77 | PIK3CG (0.50) | AURKABRAFPLK4JAK2ROCK2 | |
| SCHEMBL4120005 | 0.76 | SYK (0.46) | AURKABRAFPLK4JAK2ROCK2 | |
| SCHEMBL9887961 | 0.76 | AURKA (0.46) | AURKABRAFPLK4JAK2ROCK2 | |
| SCHEMBL4828101 | 0.75 | AURKA (0.54) | AURKABRAFPLK4JAK2ROCK2 | |
| SCHEMBL28046056 | 0.75 | BRAF (0.53) | AURKABRAFPLK4JAK2ROCK2 | |
| SCHEMBL298571 | 0.74 | BRAF (0.63) | AURKABRAFPLK4MAP4K4FES | |
| SCHEMBL27043050 | 0.74 | PIK3CG (0.40) | AURKABRAFPLK4JAK2ROCK2 | |
| SCHEMBL1516568 | 0.73 | DYRK1A (0.48) | AURKABRAFPLK4JAK2ROCK2 | |
| SCHEMBL4831062 | 0.73 | DYRK1A (0.48) | AURKABRAFPLK4JAK2ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220169644-A1 | BICYCLIC HPK1 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2022-06-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220169644-A1 | BICYCLIC HPK1 INHIBITORS | PCK1, PGK1, PDXK | AURKA 972/4885TPX2 51/4885BRAF 1037/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.