Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 2/20 | 0.67 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | SNCA | P37840 | 2/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 8/20 | 0.37 |
| ▸ | TRAP1 | Q12931 | 2/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | GSK3B | P49841 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8376142 | 0.89 | HIF1A (0.58) | HIF1ATSHRALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL8374692 | 0.89 | HIF1A (0.58) | HIF1ATSHRALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL8375270 | 0.89 | HIF1A (0.58) | HIF1ATSHRALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL8604643 | 0.89 | HIF1A (0.58) | HIF1ATSHRALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL8372333 | 0.89 | HIF1A (0.58) | HIF1ATSHRALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL8373298 | 0.89 | HIF1A (0.58) | HIF1ATSHRALDH1A1CYP1A2CYP2D6 | |
| Bromide SCHEMBL3687988 | 0.84 | HIF1A (0.58) | HIF1ATSHRALDH1A1CYP1A2CYP2D6 | |
| Bromide SCHEMBL2447020 | 0.84 | HIF1A (0.94) | HIF1ATSHRALDH1A1CYP1A2CYP2D6 | |
| Acetic Acid SCHEMBL11664326 | 0.82 | ALDH1A1 (0.53) | HIF1ATSHRALDH1A1CYP1A2CYP2D6 | |
| Hydrochloric Acid SCHEMBL27863291 | 0.81 | HIF1A (0.61) | HIF1ATSHRALDH1A1CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10928728-B2 | Photoactivable nitrogen bases | BASF SE (DE) | 2021-02-23 | — | — | US | disclosed |
| US-20210033972-A1 | PHOTOACTIVABLE NITROGEN BASES | BASF SE (DE) | 2021-02-04 | — | — | US | disclosed |
| US-20180217498-A1 | PHOTOACTIVABLE NITROGEN BASES | BASF SE (DE) | 2018-08-02 | — | — | US | disclosed |
| US-9921477-B2 | Photoactivable nitrogen bases | BASE SE (DE) | 2018-03-20 | — | — | US | disclosed |
| CN-101641643-B | Photoactivable nitrogen bases | BASF SE | 2013-08-07 | — | — | CN | disclosed |
| EP-2145231-B1 | PHOTOACTIVABLE NITROGEN BASES | BASF SE (DE) | 2011-09-14 | — | — | EP | disclosed |
| US-20100105794-A1 | PHOTOACTIVABLE NITROGEN BASES | CIBA CORPORATION (US) | 2010-04-29 | — | — | US | disclosed |
| CN-101641643-A | Photoactivable nitrogen bases | CIBA HOLDING INC DE | 2010-02-03 | — | — | CN | disclosed |
| EP-2145231-A1 | PHOTOACTIVABLE NITROGEN BASES | BASF SE (DE) | 2010-01-20 | — | — | EP | disclosed |
| WO-2008119688-A1 | PHOTOACTIVABLE NITROGEN BASES | BASF SE (CH) | 2008-10-09 | — | — | WO | disclosed |
| EP-0970085-B1 | PHOTOACTIVATABLE NITROGEN-CONTAINING BASES BASED ON ALPHA-AMINO ALKENES | CIBA SC HOLDING AG (CH) | 2002-07-24 | — | — | EP | disclosed |
| US-6087070-A | AS PHOTOINITIATORS FOR BASE-CATALYZABLE REACTIONS | CIBA SPECIALTY CHEMICALS CORPORATION (US) | 2000-07-11 | — | — | US | disclosed |
| EP-0970085-A1 | PHOTOACTIVATABLE NITROGEN-CONTAINING BASES BASED ON $g(a)-AMINO ALKENES | Ciba SC Holding AG (CH) | 2000-01-12 | — | — | EP | disclosed |
| WO-1998041524-A1 | PHOTOACTIVATABLE NITROGEN-CONTAINING BASES BASED ON α-AMINO ALKENES | CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) | 1998-09-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210033972-A1 | PHOTOACTIVABLE NITROGEN BASES | CBR1, ARNT, NR0B1 | HIF1A 1258/4885TSHR 752/4885ALDH1A1 1659/4885 |
| US-10928728-B2 | Photoactivable nitrogen bases | CBR1, NR0B1, NR0B2 | HIF1A 1136/4885TSHR 801/4885ALDH1A1 1733/4885 |
| US-20180217498-A1 | PHOTOACTIVABLE NITROGEN BASES | CBR1, NR0B1, NR0B2 | HIF1A 1136/4885TSHR 801/4885ALDH1A1 1733/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.