Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | PKM | P14618 | 2/20 | 0.55 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.50 |
| ▸ | PLG | P00747 | 1/20 | 0.47 |
| ▸ | LTA4H | P09960 | 1/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 2/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | CA9 | Q16790 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10768177 | 0.80 | PKM (0.78) | LMNAPKMNOTUMGAAPTK2 | |
| SCHEMBL13667800 | 0.78 | PKM (0.58) | LMNAPKMNOTUMGAAPTK2 | |
| SCHEMBL1010203 | 0.75 | MYC (0.62) | LMNAPKMNOTUMGAAPTK2 | |
| SCHEMBL4263728 | 0.75 | PKM (0.64) | LMNAPKMNOTUMGAAPTK2 | |
| SCHEMBL1160951 | 0.75 | PKM (0.64) | LMNAPKMNOTUMGAAPTK2 | |
| SCHEMBL1738380 | 0.73 | POLB (0.82) | POLBPLGCYP2D6CA12CA1 | |
| SCHEMBL7995967 | 0.73 | PKM (0.62) | LMNAPKMNOTUMGAAPTK2 | |
| SCHEMBL6170243 | 0.71 | IMPDH2 (0.73) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL2449213 | 0.71 | KMT2A (0.58) | LMNAPKMNOTUMGAAPTK2 | |
| SCHEMBL13913454 | 0.71 | PKM (0.50) | LMNAPKMNOTUMGAAPTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2367826-A1 | MODULATORS OF AMYLOID BETA. | AstraZeneca AB (SE) | 2011-09-28 | — | — | EP | disclosed |
| WO-2010053438-A1 | MODULATORS OF AMYLOID BETA. | ASTRAZENECA AB (SE) | 2010-05-14 | — | — | WO | disclosed |