Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPX4 | P36969 | 6/20 | 0.70 |
| ▸ | CACNA2D1 | P54289 | 5/20 | 0.62 |
| ▸ | CACNB1 | Q02641 | 5/20 | 0.62 |
| ▸ | CACNA1B | Q00975 | 4/20 | 0.62 |
| ▸ | CACNA1C | Q13936 | 3/20 | 0.62 |
| ▸ | CACNA1G | O43497 | 3/20 | 0.62 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.61 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.55 |
| ▸ | TACR3 | P29371 | 1/20 | 0.52 |
| ▸ | FNTA | P49354 | 1/20 | 0.52 |
| ▸ | FNTB | P49356 | 1/20 | 0.52 |
| ▸ | MGLL | Q99685 | 1/20 | 0.51 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL917195 | 0.77 | GPX4 (0.69) | GPX4CACNA2D1CACNB1CACNA1BCACNA1C | |
| SCHEMBL5013016 | 0.77 | CACNA1G (0.70) | GPX4CACNA2D1CACNB1CACNA1BCACNA1C | |
| SCHEMBL5268519 | 0.77 | CACNA2D1 (1.00) | GPX4CACNA2D1CACNB1CACNA1BCACNA1C | |
| SCHEMBL4179713 | 0.77 | CACNA2D1 (1.00) | GPX4CACNA2D1CACNB1CACNA1BCACNA1C | |
| SCHEMBL5266301 | 0.77 | CACNA2D1 (1.00) | GPX4CACNA2D1CACNB1CACNA1BCACNA1C | |
| SCHEMBL17281595 | 0.76 | GPX4 (0.68) | GPX4CACNA2D1CACNB1CACNA1BCACNA1C | |
| SCHEMBL7665618 | 0.76 | NPC1 (0.78) | GPX4CACNA2D1CACNB1CACNA1BCACNA1C | |
| SCHEMBL5544042 | 0.76 | CACNA2D1 (1.00) | GPX4CACNA2D1CACNB1CACNA1BCACNA1C | |
| SCHEMBL24496402 | 0.74 | GPX4 (0.64) | GPX4CACNA2D1CACNB1CACNA1BCACNA1C | |
| SCHEMBL1446803 | 0.73 | NPC1 (0.85) | GPX4CACNA2D1CACNB1CACNA1BCACNA1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022119362-A1 | GPX4 PROTEIN DEGRADATION-INDUCING COMPOUND | (주) 업테라 | 2022-06-09 | — | — | WO | disclosed |