Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPX4 | P36969 | 7/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.56 |
| ▸ | CACNA2D1 | P54289 | 5/20 | 0.54 |
| ▸ | CACNB1 | Q02641 | 5/20 | 0.54 |
| ▸ | CACNA1B | Q00975 | 4/20 | 0.54 |
| ▸ | CACNA1C | Q13936 | 3/20 | 0.54 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.54 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.54 |
| ▸ | MGLL | Q99685 | 2/20 | 0.53 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.53 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31351089 | 0.85 | KMT2A (0.71) | CYP3A4CACNA2D1CACNB1CACNA1BCACNA1C | |
| SCHEMBL17281595 | 0.84 | GPX4 (0.68) | GPX4CYP3A4CYP3A5CACNA2D1CACNB1 | |
| SCHEMBL917195 | 0.80 | GPX4 (0.69) | GPX4CACNA2D1CACNB1CACNA1BCACNA1C | |
| SCHEMBL16769444 | 0.79 | KMT2A (0.82) | GPX4CYP3A4CYP3A5CACNA2D1CACNB1 | |
| SCHEMBL13309468 | 0.79 | KMT2A (0.82) | GPX4CYP3A4CYP3A5CACNA2D1CACNB1 | |
| SCHEMBL24496176 | 0.75 | GPX4 (1.00) | GPX4CACNA2D1CACNB1CACNA1BCACNA1C | |
| SCHEMBL24496348 | 0.74 | GPX4 (0.70) | GPX4CACNA2D1CACNB1CACNA1BCACNA1C | |
| SCHEMBL17276580 | 0.74 | MGLL (0.64) | GPX4CYP3A4CYP3A5CACNA2D1CACNB1 | |
| SCHEMBL4152763 | 0.74 | SLC6A9 (0.67) | GPX4CYP3A4CACNA2D1CACNB1CACNA1B | |
| SCHEMBL13309487 | 0.73 | CACNA2D1 (0.67) | GPX4CYP3A4CACNA2D1CACNB1CACNA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022119362-A1 | GPX4 PROTEIN DEGRADATION-INDUCING COMPOUND | (주) 업테라 | 2022-06-09 | — | — | WO | disclosed |