Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK1 | P51617 | 2/20 | 0.53 |
| ▸ | IRAK3 | Q9Y616 | 2/20 | 0.53 |
| ▸ | GPR119 | Q8TDV5 | 14/20 | 0.43 |
| ▸ | CCNC | P24863 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.41 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.40 |
| ▸ | RAF1 | P04049 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29648294 | 1.00 | IRAK1 (0.53) | IRAK1IRAK3GPR119CCNCCDK8 | |
| SCHEMBL30962354 | 0.94 | IRAK1 (0.47) | IRAK1IRAK3GPR119CRBNIRAK4 | |
| SCHEMBL27466428 | 0.94 | IRAK1 (0.47) | IRAK1IRAK3GPR119CRBNIRAK4 | |
| SCHEMBL30694690 | 0.91 | GPR119 (0.45) | IRAK1IRAK3GPR119CRBN | |
| SCHEMBL21907830 | 0.91 | GPR119 (0.45) | IRAK1IRAK3GPR119CRBN | |
| SCHEMBL30962346 | 0.87 | IRAK1 (0.43) | IRAK1IRAK3GPR119CRBNIRAK4 | |
| SCHEMBL31620804 | 0.86 | CRBN (0.57) | IRAK1IRAK3CCNCCDK8NTRK3 | |
| SCHEMBL22291403 | 0.86 | CRBN (0.57) | IRAK1IRAK3CCNCCDK8NTRK3 | |
| SCHEMBL29648407 | 0.86 | CRBN (0.57) | IRAK1IRAK3CCNCCDK8NTRK3 | |
| SCHEMBL24501945 | 0.86 | CRBN (0.57) | IRAK1IRAK3CCNCCDK8NTRK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022120355-A1 | TEAD DEGRADERS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-06-09 | — | — | WO | disclosed |