Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 9/20 | 0.45 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.45 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.44 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.44 |
| ▸ | IRAK3 | Q9Y616 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.42 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21907830 | 1.00 | GPR119 (0.45) | GPR119PDK2CRBNIRAK1IRAK3 | |
| SCHEMBL24501045 | 0.91 | IRAK1 (0.53) | GPR119CRBNIRAK1IRAK3 | |
| SCHEMBL29648294 | 0.91 | IRAK1 (0.53) | GPR119CRBNIRAK1IRAK3 | |
| SCHEMBL30962354 | 0.91 | IRAK1 (0.47) | GPR119PDK2CRBNIRAK1IRAK3 | |
| SCHEMBL27466428 | 0.91 | IRAK1 (0.47) | GPR119PDK2CRBNIRAK1IRAK3 | |
| SCHEMBL27176453 | 0.86 | CRBN (0.48) | CRBNIRAK1IRAK3ALDH1A1MAPT | |
| SCHEMBL30962346 | 0.85 | IRAK1 (0.43) | GPR119PDK2CRBNIRAK1IRAK3 | |
| SCHEMBL20234679 | 0.84 | CRBN (0.45) | GPR119PDK2CRBNALDH1A1MAPT | |
| SCHEMBL31047986 | 0.84 | CRBN (0.45) | GPR119PDK2CRBNALDH1A1MAPT | |
| SCHEMBL27466391 | 0.84 | PDK2 (0.45) | GPR119PDK2CRBNALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117295523-A | PXR-targeted difunctional PROTAC compound, preparation method and therapeutic application thereof | 国家科学研究中心 | 2023-12-26 | — | — | CN | disclosed |