Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 known ✓ | P04049 | 2/20 | 0.35 |
| ▸ | SYK known ✓ | P43405 | 1/20 | 0.35 |
| ▸ | PDK2 known ✓ | Q15119 | 1/20 | 0.34 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.43 |
| ▸ | IRAK3 | Q9Y616 | 2/20 | 0.43 |
| ▸ | CRBN | Q96SW2 | 7/20 | 0.39 |
| ▸ | AR | P10275 | 4/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30962354 | 0.93 | IRAK1 (0.47) | IRAK1IRAK3CRBNARCDK9 | |
| SCHEMBL27466428 | 0.93 | IRAK1 (0.47) | IRAK1IRAK3CRBNARCDK9 | |
| SCHEMBL29648294 | 0.87 | IRAK1 (0.53) | IRAK1IRAK3CRBNGPR119IRAK4 | |
| SCHEMBL24501045 | 0.87 | IRAK1 (0.53) | IRAK1IRAK3CRBNGPR119IRAK4 | |
| SCHEMBL21907830 | 0.85 | GPR119 (0.45) | IRAK1IRAK3CRBNGPR119PDK2 | |
| SCHEMBL30694690 | 0.85 | GPR119 (0.45) | IRAK1IRAK3CRBNGPR119PDK2 | |
| SCHEMBL20234891 | 0.80 | CRBN (0.58) | IRAK1IRAK3CRBNARCDK9 | |
| SCHEMBL29802963 | 0.80 | CRBN (0.58) | IRAK1IRAK3CRBNARCDK9 | |
| SCHEMBL29927426 | 0.79 | CRBN (0.58) | IRAK1IRAK3CRBNARCDK9 | |
| SCHEMBL29132100 | 0.79 | CRBN (0.58) | IRAK1IRAK3CRBNARCDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4633732-A1 | HETEROCYCLIC COMPOUNDS TARGETING THE NUDT5 PROTEIN | Oxford University Innovation Limited (GB) | 2025-10-22 | — | — | EP | disclosed |
| WO-2024127022-A1 | HETEROCYCLIC COMPOUNDS TARGETING THE NUDT5 PROTEIN | OXFORD UNIVERSITY INNOVATION LIMITED (GB) | 2024-06-20 | — | — | WO | disclosed |