Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK1 | P51617 | 2/20 | 0.47 |
| ▸ | IRAK3 | Q9Y616 | 2/20 | 0.47 |
| ▸ | CRBN | Q96SW2 | 5/20 | 0.42 |
| ▸ | AR | P10275 | 3/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.38 |
| ▸ | RAF1 | P04049 | 2/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30962354 | 1.00 | IRAK1 (0.47) | IRAK1IRAK3CRBNARGPR119 | |
| SCHEMBL29648294 | 0.94 | IRAK1 (0.53) | IRAK1IRAK3CRBNGPR119IRAK4 | |
| SCHEMBL24501045 | 0.94 | IRAK1 (0.53) | IRAK1IRAK3CRBNGPR119IRAK4 | |
| SCHEMBL30962346 | 0.93 | IRAK1 (0.43) | IRAK1IRAK3CRBNARGPR119 | |
| SCHEMBL21907830 | 0.91 | GPR119 (0.45) | IRAK1IRAK3CRBNGPR119PDK2 | |
| SCHEMBL30694690 | 0.91 | GPR119 (0.45) | IRAK1IRAK3CRBNGPR119PDK2 | |
| SCHEMBL20234891 | 0.85 | CRBN (0.58) | IRAK1IRAK3CRBNARIRAK4 | |
| SCHEMBL29802963 | 0.85 | CRBN (0.58) | IRAK1IRAK3CRBNARIRAK4 | |
| SCHEMBL29927426 | 0.85 | CRBN (0.58) | IRAK1IRAK3CRBNARIRAK4 | |
| SCHEMBL29132100 | 0.85 | CRBN (0.58) | IRAK1IRAK3CRBNARIRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024127022-A1 | HETEROCYCLIC COMPOUNDS TARGETING THE NUDT5 PROTEIN | OXFORD UNIVERSITY INNOVATION LIMITED (GB) | 2024-06-20 | — | — | WO | disclosed |