Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | RHEB | Q15382 | 2/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA4 | P22748 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27294277 | 1.00 | ALDH1A1 (0.35) | ALDH1A1HPGDGFERPOLBGAA | |
| SCHEMBL24501048 | 1.00 | ALDH1A1 (0.35) | ALDH1A1HPGDGFERPOLBGAA | |
| SCHEMBL24500977 | 1.00 | ALDH1A1 (0.35) | ALDH1A1HPGDGFERPOLBGAA | |
| SCHEMBL19449335 | 0.80 | POLB (0.44) | ALDH1A1HPGDGFERPOLBGAA | |
| SCHEMBL22717781 | 0.78 | POLB (0.40) | ALDH1A1HPGDGFERPOLBGAA | |
| SCHEMBL24501494 | 0.77 | POLB (0.47) | ALDH1A1HPGDGFERPOLBGAA | |
| SCHEMBL24501402 | 0.76 | POLB (0.31) | POLB | |
| SCHEMBL29695012 | 0.76 | POLB (0.31) | POLB | |
| SCHEMBL24501497 | 0.76 | POLB (0.31) | POLB | |
| SCHEMBL24501399 | 0.76 | POLB (0.31) | POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4532493-A1 | THIADIAZOLYL DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS AND USES THEREOF | Ideaya Biosciences, Inc. (US) | 2025-04-09 | — | — | EP | disclosed |
| CN-119451954-A | Thiadiazolyl derivatives as DNA polymerase theta inhibitors and uses thereof | 伊迪亚生物科学有限公司 | 2025-02-14 | — | — | CN | disclosed |
| WO-2023233295-A1 | THIADIAZOLYL DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS AND USES THEREOF | IDEAYA BIOSCIENCES, INC. (US) | 2023-12-07 | — | — | WO | disclosed |
| WO-2023233295-A1 | THIADIAZOLYL DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS AND USES THEREOF | IDEAYA BIOSCIENCES, INC. (US) | 2023-12-07 | — | — | WO | disclosed |
| WO-2022118210-A1 | SUBSTITUTED THIADIAZOLYL DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2022-06-09 | — | — | WO | disclosed |