Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRAP1 | Q12931 | 3/20 | 0.53 |
| ▸ | HSP90B1 | P14625 | 2/20 | 0.53 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.51 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.50 |
| ▸ | NAMPT | P43490 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.45 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.45 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.45 |
| ▸ | GPR183 | P32249 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | DRD1 | P21728 | 1/20 | 0.44 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.44 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24503025 | 0.89 | ABHD6 (0.54) | HSD11B1ABHD6NAMPTHPGDLMNA | |
| SCHEMBL4505014 | 0.86 | ABHD6 (0.48) | TRAP1HSP90B1ABHD6NAMPTHPGD | |
| SCHEMBL26525246 | 0.81 | GPR183 (0.51) | ABHD6NAMPTHPGDDPP8DPP9 | |
| SCHEMBL24685025 | 0.77 | TRAP1 (0.55) | TRAP1HSP90B1NAMPTHPGDDPP8 | |
| SCHEMBL4437450 | 0.75 | ABHD6 (0.55) | ABHD6NAMPTDPP8DPP9DPP7 | |
| SCHEMBL1956852 | 0.75 | ABHD6 (0.55) | ABHD6NAMPTDPP8DPP9DPP7 | |
| SCHEMBL18085956 | 0.74 | TRAP1 (0.55) | TRAP1HSP90B1NAMPTKDM4EMEN1 | |
| SCHEMBL16101941 | 0.74 | NOTUM (0.60) | ABHD6NAMPTDPP8DPP9DPP7 | |
| SCHEMBL20439780 | 0.74 | HPGD (0.59) | ABHD6NAMPTHPGDLMNAHTT | |
| SCHEMBL25592808 | 0.73 | CA12 (0.44) | TRAP1HSP90B1HSD11B1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4257588-A1 | SMALL MOLECULE INHIBITOR OF CATHEPSIN C AND MEDICINAL USE THEREOF | Reistone Biopharma Company Limited (CN) | 2023-10-11 | — | — | EP | disclosed |
| WO-2022117059-A1 | SMALL MOLECULE INHIBITOR OF CATHEPSIN C AND MEDICINAL USE THEREOF | 瑞石生物医药有限公司 | 2022-06-09 | — | — | WO | disclosed |