Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | PREP | P48147 | 2/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30171988 | 0.86 | HRH3 (0.41) | BTKHSD17B10HRH3CHRM2CHRM1 | |
| SCHEMBL6121092 | 0.85 | ALDH1A1 (0.44) | BTKHRH3KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL21159154 | 0.85 | ALDH1A1 (0.44) | BTKHRH3KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL6926352 | 0.85 | CHRM2 (0.40) | BTKHRH3CHRM2CHRM1CHRM3 | |
| SCHEMBL12968568 | 0.85 | CHRM2 (0.40) | BTKHRH3CHRM2CHRM1CHRM3 | |
| SCHEMBL1409871 | 0.82 | BTK (0.47) | BTKHSD17B10HRH3CHRM2CHRM1 | |
| SCHEMBL16213867 | 0.81 | HRH3 (0.38) | BTKHRH3CHRM2CHRM1CHRM3 | |
| SCHEMBL17893456 | 0.79 | PPM1B (0.47) | KMT2AALDH1A1POLB | |
| SCHEMBL23925520 | 0.79 | BTK (0.40) | BTKHRH3CHRM2CHRM1CHRM3 | |
| SCHEMBL28473594 | 0.79 | BTK (0.46) | BTKHSD17B10HRH3CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2364311-A1 | TROPANE UREA DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC APPLICATION THEREOF AS MODULATORS OF THE ACTIVITY OF 11BETAHSD1 | SANOFI (FR) | 2011-09-14 | — | — | EP | disclosed |
| WO-2010049635-A1 | TROPANE UREA DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC APPLICATION THEREOF AS MODULATORS OF THE ACTIVITY OF 11BETAHSD1 | SANOFI-AVENTIS (FR) | 2010-05-06 | — | — | WO | disclosed |