Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.71 |
| ▸ | NPC1 | O15118 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.61 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | CA12 | O43570 | 2/20 | 0.58 |
| ▸ | CA1 | P00915 | 2/20 | 0.58 |
| ▸ | CA2 | P00918 | 2/20 | 0.58 |
| ▸ | CA9 | Q16790 | 2/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11278088 | 0.85 | PTGS1 (0.65) | HTTNPC1SMN1; SMN2LMNAERCC1 | |
| Anisole SCHEMBL27932714 | 0.85 | NPC1 (0.62) | HTTNPC1SMN1; SMN2LMNAERCC1 | |
| SCHEMBL26099203 | 0.85 | SMN1; SMN2 (0.70) | HTTNPC1SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL14817500 | 0.84 | RAB9A (0.61) | HTTNPC1SMN1; SMN2LMNAERCC1 | |
| SCHEMBL8951696 | 0.84 | HTT (0.69) | HTTNPC1SMN1; SMN2LMNAERCC1 | |
| SCHEMBL10963044 | 0.84 | HTT (0.69) | HTTNPC1SMN1; SMN2LMNAERCC1 | |
| SCHEMBL24064509 | 0.83 | ALDH1A1 (0.68) | HTTNPC1SMN1; SMN2LMNAERCC1 | |
| SCHEMBL20325057 | 0.83 | POLB (0.74) | SMN1; SMN2ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL13933261 | 0.82 | HTT (0.51) | HTTNPC1SMN1; SMN2LMNAERCC1 | |
| SCHEMBL3369060 | 0.81 | HTT (0.76) | HTTNPC1SMN1; SMN2LMNAERCC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8013153-B2 | Substituted pyrimidine kinase inhibitors | JANSSEN PHARMACEUTICA, N.V. (BE) | 2011-09-06 | — | — | US | disclosed |
| US-20070254896-A1 | SUBSTITUTED PYRIMIDINE KINASE INHIBITORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-11-01 | — | — | US | disclosed |
| WO-2007109783-A2 | SUBSTITUTED PYRIMIDINE KINASE INHIBITORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-09-27 | — | — | WO | disclosed |
| US-5110914-A | Ion exchanging | UNIVERSITY OF MIAMI (US) | 1992-05-05 | — | — | US | disclosed |
| US-5086167-A | Ion exchanging with a ligand/matrix using a combination of pi-electron and electrostatic interaction of the ligand and ionic amino acids | UNIVERSITY OF MIAMI (US) | 1992-02-04 | — | — | US | disclosed |
| EP-0371746-A2 | Method of separating proteins | UNIVERSITY OF MIAMI (US) | 1990-06-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070254896-A1 | SUBSTITUTED PYRIMIDINE KINASE INHIBITORS | DTYMK, TK1, DCK | HTT 4395/4885NPC1 1789/4885SMN1; SMN2 2628/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.