Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.36 |
| ▸ | MEN1 | O00255 | 5/20 | 0.36 |
| ▸ | MAPT | P10636 | 5/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | MIF | P14174 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24512550 | 0.81 | ALDH1A1 (0.39) | ALDH1A1POLBSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL24512630 | 0.81 | HPGD (0.38) | ALDH1A1POLBSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL24512559 | 0.77 | ALDH1A1 (0.38) | ALDH1A1POLBSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL24512761 | 0.74 | CREBBP (0.34) | ALDH1A1NPSR1LMNACYP1A2TSHR | |
| SCHEMBL3540104 | 0.70 | ALDH1A1 (0.52) | ALDH1A1POLBSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL9380892 | 0.69 | NOS1 (0.42) | NPSR1LMNACYP1A2TSHRKDM4E | |
| SCHEMBL25415875 | 0.68 | MAPT (0.47) | ALDH1A1POLBSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL3408623 | 0.66 | ALDH1A1 (0.51) | ALDH1A1POLBSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL31556440 | 0.65 | ERCC5 (0.48) | — | |
| SCHEMBL10147411 | 0.65 | SMN1; SMN2 (0.50) | ALDH1A1POLBSMN1; SMN2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220185815-A1 | PYRROLOPYRAZOLE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2022-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220185815-A1 | PYRROLOPYRAZOLE DERIVATIVE | PTDSS1, PTDSS2, SMPD1 | ALDH1A1 2761/4885POLB 3262/4885SMN1; SMN2 3455/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.