Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 4/20 | 0.42 |
| ▸ | NOS2 | P35228 | 3/20 | 0.42 |
| ▸ | NOS3 | P29474 | 2/20 | 0.42 |
| ▸ | GRIN2D | O15399 | 3/20 | 0.39 |
| ▸ | GRIN3B | O60391 | 3/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.39 |
| ▸ | GRIN2C | Q14957 | 3/20 | 0.39 |
| ▸ | GRIN3A | Q8TCU5 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | KMO | O15229 | 1/20 | 0.36 |
| ▸ | OGT | O15294 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | THPO | P40225 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9380463 | 0.82 | KMO (0.37) | NOS1NOS2NOS3KDM4EKMO | |
| SCHEMBL30468841 | 0.82 | KMO (0.37) | NOS1NOS2NOS3KDM4EKMO | |
| SCHEMBL27474482 | 0.80 | AR (0.42) | NOS1NOS2NOS3GRIN2DGRIN3B | |
| SCHEMBL2149212 | 0.80 | NOS1 (0.53) | NOS1NOS2NOS3GRIN2DGRIN3B | |
| SCHEMBL24207806 | 0.79 | KMO (0.35) | NOS1NOS2NOS3KDM4EKMO | |
| SCHEMBL24512761 | 0.78 | CREBBP (0.34) | NOS1NOS2NOS3KDM4EKMO | |
| SCHEMBL16362079 | 0.77 | NOS1 (0.42) | NOS1NOS2NOS3GRIN2DGRIN3B | |
| SCHEMBL4878589 | 0.77 | NOS1 (0.46) | NOS1NOS2NOS3GRIN2DGRIN3B | |
| SCHEMBL30445055 | 0.77 | NOS1 (0.42) | NOS1NOS2NOS3GRIN2DGRIN3B | |
| SCHEMBL18415160 | 0.77 | NOS1 (0.42) | NOS1NOS2NOS3GRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220185815-A1 | PYRROLOPYRAZOLE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2022-06-16 | — | — | US | disclosed |
| EP-0409484-B1 | 4,5,6,7-Tetrasubstituted benzoxazolones | PFIZER (US) | 1994-06-08 | — | — | EP | disclosed |
| US-5071863-A | Antiallergens; antiinflammatory agents; enzyme inhibitors | PFIZER INC. (US) | 1991-12-10 | — | — | US | disclosed |
| EP-0409484-A2 | 4,5,6,7-Tetrasubstituted benzoxazolones | PFIZER INC. (US) | 1991-01-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220185815-A1 | PYRROLOPYRAZOLE DERIVATIVE | PTDSS1, PTDSS2, SMPD1 | NOS1 1844/4885NOS2 2557/4885NOS3 2068/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.