Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 9/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.34 |
| ▸ | DAO | P14920 | 2/20 | 0.33 |
| ▸ | MAOB | P27338 | 4/20 | 0.33 |
| ▸ | MAOA | P21397 | 2/20 | 0.33 |
| ▸ | CA12 | O43570 | 2/20 | 0.32 |
| ▸ | CA9 | Q16790 | 2/20 | 0.32 |
| ▸ | CES2 | O00748 | 1/20 | 0.32 |
| ▸ | CES1 | P23141 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | NT5E | P21589 | 1/20 | 0.31 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3525876 | 0.85 | ADRA2A (0.40) | GRM5ADRA2ACLCN2MAOACES2 | |
| SCHEMBL6183467 | 0.84 | ALDH1A1 (0.38) | GRM5ADRA2ACLCN2MAOBCES2 | |
| SCHEMBL24512559 | 0.74 | ALDH1A1 (0.38) | KDM4ECYP1A2 | |
| SCHEMBL24204705 | 0.73 | MCL1 (0.32) | ADRA2ACA12CA9CYP1A2 | |
| SCHEMBL5492582 | 0.70 | MAPT (0.53) | MAOBMAOACA9KDM4E | |
| SCHEMBL24512624 | 0.70 | OGT (0.43) | GRM5MAOBMAOACA12CA9 | |
| SCHEMBL24512761 | 0.68 | CREBBP (0.34) | ADRA2AMAOBMAOACA12CA9 | |
| 4-Acetyl-2-Benzoxazolinone SCHEMBL3546681 | 0.67 | GRM5 (0.64) | GRM5MAOBCA12CA9KDM4E | |
| SCHEMBL21951039 | 0.66 | ALDH1A1 (0.37) | MAOBMAOACA9KDM4E | |
| SCHEMBL29670890 | 0.65 | MCL1 (0.49) | GRM5ADRA2ADAOCA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220185815-A1 | PYRROLOPYRAZOLE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2022-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220185815-A1 | PYRROLOPYRAZOLE DERIVATIVE | PTDSS1, PTDSS2, SMPD1 | GRM5 3540/4885ADRA2A 4728/4885CLCN2 2962/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.