Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 5/20 | 0.59 |
| ▸ | F10 | P00742 | 1/20 | 0.59 |
| ▸ | NOS1 | P29475 | 5/20 | 0.46 |
| ▸ | NOS2 | P35228 | 5/20 | 0.46 |
| ▸ | NOS3 | P29474 | 3/20 | 0.46 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.45 |
| ▸ | PLAU | P00749 | 2/20 | 0.41 |
| ▸ | ABAT | P80404 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.39 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.39 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | PLG | P00747 | 1/20 | 0.38 |
| ▸ | PLAT | P00750 | 1/20 | 0.38 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21262437 | 0.78 | NQO2 (0.41) | NOS1NOS2NOS3PLAUPRSS1 | |
| SCHEMBL24620530 | 0.77 | LOXL2 (0.64) | LOXL2F10NOS1NOS2NOS3 | |
| SCHEMBL24964824 | 0.76 | LMNA (0.54) | PLAUSMN1; SMN2KDM4EALDH1A1CYP3A4 | |
| SCHEMBL49594 | 0.74 | LOXL2 (1.00) | LOXL2F10ST14PLAUABAT | |
| Hydrochloric Acid SCHEMBL1981173 | 0.73 | LOXL2 (0.95) | LOXL2F10ST14PLAUPRSS1 | |
| Hydrochloric Acid SCHEMBL322008 | 0.73 | LOXL2 (0.95) | LOXL2F10ST14PLAUPRSS1 | |
| SCHEMBL22143896 | 0.69 | TSHR (0.55) | NOS1ALDH1A1 | |
| SCHEMBL3191980 | 0.69 | LOXL2 (0.48) | LOXL2F10NOS1NOS2NOS3 | |
| SCHEMBL21697117 | 0.69 | LOXL2 (0.52) | LOXL2F10NOS1NOS2NOS3 | |
| SCHEMBL20880151 | 0.69 | LOXL2 (0.64) | LOXL2F10NOS1NOS2NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022125804-A1 | SMARCA DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2022-06-16 | — | — | WO | disclosed |