Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHKA | P35790 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | NCF1 | P14598 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.55 |
| ▸ | GFER | P55789 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.55 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.55 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.47 |
| ▸ | APP | P05067 | 1/20 | 0.47 |
| ▸ | F10 | P00742 | 3/20 | 0.46 |
| ▸ | HTR3A | P46098 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1433274 | 0.92 | MAPT (0.63) | CHKALMNANCF1ALDH1A1KDM4E | |
| SCHEMBL25888837 | 0.86 | ALDH1A1 (0.57) | CHKALMNAALDH1A1KDM4EGAA | |
| SCHEMBL18815076 | 0.85 | LTA4H (0.52) | CHKALMNAALDH1A1KDM4EGAA | |
| SCHEMBL82022 | 0.82 | CHKA (0.64) | CHKALMNANCF1ALDH1A1KDM4E | |
| SCHEMBL625677 | 0.81 | ALDH1A1 (0.54) | CHKALMNAALDH1A1KDM4EGAA | |
| SCHEMBL14345952 | 0.81 | AKR1C3 (0.57) | LMNAALDH1A1KDM4EGAAMAPT | |
| SCHEMBL20907277 | 0.81 | CHKA (0.62) | CHKALMNANCF1ALDH1A1KDM4E | |
| SCHEMBL24596933 | 0.81 | CHKA (0.62) | CHKALMNANCF1ALDH1A1KDM4E | |
| SCHEMBL14922271 | 0.81 | CHKA (0.62) | CHKALMNANCF1ALDH1A1KDM4E | |
| SCHEMBL217159 | 0.81 | MAPT (0.85) | CHKALMNANCF1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022124748-A1 | PYRAZOLOPYRIMIDINE SULFONAMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION FOR PROPHYLAXIS OR TREATMENT OF CANCER-RELATED DISEASE COMPRISING SAME AS ACTIVE INGREDIENT | 한국화학연구원 | 2022-06-16 | — | — | WO | disclosed |