SCHEMBL24521471

SCHEMBL24521471

CCCC(=O)N1CCN(CC2CCN(C(=O)CC)CC2)CC1

nearest known ligand 0.47

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HSD11B1 P28845 1/20 0.47
HRH3 Q9Y5N1 1/20 0.45
CACNA2D1 P54289 1/20 0.44
CACNA1B Q00975 1/20 0.44
CACNB1 Q02641 1/20 0.44
CACNA1C Q13936 1/20 0.44
GNAI3 P08754 5/20 0.43
GNAO1 P09471 5/20 0.43
GNAI1 P63096 5/20 0.43
EPHX2 P34913 5/20 0.43
EPHX1 P07099 3/20 0.43
SIGMAR1 Q99720 1/20 0.42
NPC1 O15118 1/20 0.41
TACR1 P25103 1/20 0.39
CHRNB2 P17787 1/20 0.39
CHRNA3 P32297 1/20 0.39
CHRNA4 P43681 1/20 0.39
CHRNB3 Q05901 1/20 0.39
CHRNA6 Q15825 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20471042 0.87 HRH3 (0.48) HSD11B1HRH3CACNA2D1CACNA1BCACNB1
SCHEMBL18909449 0.86 CACNA2D1 (0.45) HSD11B1HRH3CACNA2D1CACNA1BCACNB1
SCHEMBL22891213 0.85 EPHX1 (0.43) HSD11B1HRH3CACNA2D1CACNA1BCACNB1
SCHEMBL25701777 0.84 HSD11B1 (0.53) HSD11B1HRH3CACNA2D1CACNA1BCACNB1
SCHEMBL12507042 0.83 MAPT (0.49) EPHX2
SCHEMBL18909448 0.83 CACNA2D1 (0.43) HSD11B1HRH3CACNA2D1CACNA1BCACNB1
SCHEMBL18909455 0.82 PKM (0.43) CACNA2D1CACNA1BCACNB1CACNA1CEPHX2
SCHEMBL18909445 0.82 CACNA2D1 (0.42) HSD11B1HRH3CACNA2D1CACNA1BCACNB1
SCHEMBL24669826 0.82 CACNA2D1 (0.45) HSD11B1HRH3CACNA2D1CACNA1BCACNB1
SCHEMBL29317068 0.81 ACHE (0.53) CACNA2D1CACNA1BCACNB1CACNA1CEPHX2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3596072-B1 PYRAZOLOCHLOROPHENYL COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF HOFFMANN LA ROCHE (CH) 2022-06-22 EP disclosed