Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | THRB | P10828 | 5/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.32 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.32 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.32 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21085341 | 0.75 | CHRM5 (0.52) | HSD11B1SMN1; SMN2 | |
| SCHEMBL23177636 | 0.75 | EPHX2 (0.34) | SMN1; SMN2GAA | |
| SCHEMBL20937305 | 0.69 | KCNH2 (0.33) | — | |
| SCHEMBL19429648 | 0.69 | PHGDH (0.48) | MAPTSMN1; SMN2GAA | |
| SCHEMBL22520700 | 0.68 | ACHE (0.50) | HSD11B1SMN1; SMN2 | |
| SCHEMBL26480974 | 0.68 | ACHE (0.50) | HSD11B1SMN1; SMN2 | |
| SCHEMBL20109371 | 0.68 | DPP8 (0.38) | GAA | |
| SCHEMBL4469088 | 0.68 | HSD11B1 (0.45) | MAPTHSD11B1SMN1; SMN2THRBGAA | |
| SCHEMBL19157747 | 0.68 | AKR1C3 (0.30) | — | |
| SCHEMBL18389996 | 0.68 | HSD11B1 (0.45) | MAPTHSD11B1SMN1; SMN2THRBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3596072-B1 | PYRAZOLOCHLOROPHENYL COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | HOFFMANN LA ROCHE (CH) | 2022-06-22 | — | — | EP | disclosed |