SCHEMBL2452158

SCHEMBL2452158

CCCC[C@@]1(CC)CS(=O)(=O)c2cc(OC)c(OC)cc2[C@H](c2ccccc2)N1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
SLC10A2 Q12908 20/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2452163 1.00 SLC10A2 (1.00) SLC10A2
SCHEMBL1388913 1.00 SLC10A2 (1.00) SLC10A2
SCHEMBL9961457 1.00 SLC10A2 (1.00) SLC10A2
SCHEMBL2452161 1.00 SLC10A2 (1.00) SLC10A2
SCHEMBL19170267 0.94 SLC10A2 (0.88) SLC10A2
SCHEMBL14666315 0.93 SLC10A2 (1.00) SLC10A2
SCHEMBL14666333 0.93 SLC10A2 (1.00) SLC10A2
SCHEMBL16743424 0.93 SLC10A2 (1.00) SLC10A2
SCHEMBL25274089 0.92 SLC10A2 (0.85) SLC10A2
SCHEMBL2843089 0.92 SLC10A2 (0.85) SLC10A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 73 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0775126-B1 HYPOLIPIDEMIC 1,4-BENZOTHIAZEPINE-1,1-DIOXIDES WELLCOME FOUND (GB) 2002-10-30 EP claimed
US-5910494-A NOVEL COMPOUNDS THAT REDUCE THE ABSORPTION OF BILE ACIDS FROM THE INTESTINE; FOR PROPHYLAXIS AND TREATMENT OF HYPERLIPIDEMIC CONDITIONS, SUCH AS ATHEROSCLEROSIS GLAXO WELLCOME INC. (US) 1999-06-08 US claimed
US-20240207260-A1 METHODS FOR TREATING CHOLESTASIS MIRUM PHARMACEUTICALS, INC. (US) 2024-06-27 US disclosed
US-20240189308-A1 METHODS FOR TREATING CHOLESTASIS MIRUM PHARMACEUTICALS, INC. (US) 2024-06-13 US disclosed
US-11918578-B2 Methods for treating cholestasis MIRUM PHARMACEUTICALS, INC. (US) 2024-03-05 US disclosed
EP-4245367-A2 METHODS FOR TREATING CHOLESTASIS Mirum Pharmaceuticals, Inc. (US) 2023-09-20 EP disclosed
EP-4241840-A2 METHODS FOR TREATING CHOLESTASIS Mirum Pharmaceuticals, Inc. (US) 2023-09-13 EP disclosed
US-20230212211-A1 BILE ACID RECYCLING INHIBITORS FOR TREATMENT OF HYPERCHOLEMIA AND CHOLESTATIC LIVER DISEASE SHIRE HUMAN GENETIC THERAPIES, INC. (US) 2023-07-06 US disclosed
US-20230190742-A1 METHODS FOR TREATING CHOLESTASIS MIRUM PHARMACEUTICALS, INC. (US) 2023-06-22 US disclosed
EP-4137137-A1 BILE ACID RECYCLING INHIBITORS AND SATIOGENS FOR TREATMENT OF DIABETES, OBESITY, AND INFLAMMATORY GASTROINTESTINAL CONDITIONS Satiogen Pharmaceuticals, Inc. (US) 2023-02-22 EP disclosed
US-20220362238-A1 BILE ACID RECYCLING INHIBITORS AND SATIOGENS FOR TREATMENT OF DIABETES, OBESITY, AND INFLAMMATORY GASTROINTESTINAL CONDITIONS SATIOGEN PHARMACEUTICALS, INC. 2022-11-17 US disclosed
US-20090253792-A1 ACTIVE AGENT DELIVERY SYSTEMS AND METHODS FOR PROTECTING AND ADMINISTERING ACTIVE AGENTS SHIRE LLC (US) 2009-10-08 US disclosed
US-7312208-B2 Quaternary ammonium compounds ASAHI KASEI PHARMA CORPORATION (JP) 2007-12-25 US disclosed
US-20070203115-A1 Novel quaternary ammonium compounds ASAHI KASEI PHARMA CORPORATION (JP) 2007-08-30 US disclosed
EP-1535913-A1 NOVEL QUATERNARY AMMONIUM COMPOUNDS Asahi Kasei Pharma Corporation (JP) 2005-06-01 EP disclosed
EP-0775126-B1 HYPOLIPIDEMIC 1,4-BENZOTHIAZEPINE-1,1-DIOXIDES WELLCOME FOUND (GB) 2002-10-30 EP disclosed
EP-1203769-A1 Hypolipidemic 1,4-benzothiazepine derivative THE WELLCOME FOUNDATION LIMITED (GB) 2002-05-08 EP disclosed
US-5910494-A NOVEL COMPOUNDS THAT REDUCE THE ABSORPTION OF BILE ACIDS FROM THE INTESTINE; FOR PROPHYLAXIS AND TREATMENT OF HYPERLIPIDEMIC CONDITIONS, SUCH AS ATHEROSCLEROSIS GLAXO WELLCOME INC. (US) 1999-06-08 US disclosed
EP-0775126-A1 HYPOLIPIDEMIC 1,4-BENZOTHIAZEPINE-1,1-DIOXIDES THE WELLCOME FOUNDATION LIMITED (GB) 1997-05-28 EP disclosed
WO-1996005188-A1 HYPOLIPIDEMIC 1,4-BENZOTHIAZEPINE-1,1-DIOXIDES THE WELLCOME FOUNDATION LIMITED (GB) 1996-02-22 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090253792-A1 ACTIVE AGENT DELIVERY SYSTEMS AND METHODS FOR PROTECTING AND ADMINISTERING ACTIVE AGENTS HDGF, CTSA, IAPP SLC10A2 133/4885
US-20240189308-A1 METHODS FOR TREATING CHOLESTASIS SLC10A1, SLC10A2, NR1H4 SLC10A2 2/4885
US-20230212211-A1 BILE ACID RECYCLING INHIBITORS FOR TREATMENT OF HYPERCHOLEMIA AND CHOLESTATIC LIVER DISEASE SLC10A1, SLC10A2, ABCB11 SLC10A2 2/4885
US-20230190742-A1 METHODS FOR TREATING CHOLESTASIS SLC10A1, SLC10A2, ABCB11 SLC10A2 2/4885
US-20070203115-A1 Novel quaternary ammonium compounds SLC10A2, SLC10A1, ABCB11 SLC10A2 1/4885
US-20240207260-A1 METHODS FOR TREATING CHOLESTASIS SLC10A1, SLC10A2, NR1H4 SLC10A2 2/4885
US-20220362238-A1 BILE ACID RECYCLING INHIBITORS AND SATIOGENS FOR TREATMENT OF DIABETES, OBESITY, AND INFLAMMATORY GASTROINTESTINAL CONDITIONS SLC10A2, GPR119, GPBAR1 SLC10A2 1/4885
US-11918578-B2 Methods for treating cholestasis SLC10A1, SLC10A2, NR1H4 SLC10A2 2/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.