Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | PDK1 | Q15118 | 3/20 | 0.44 |
| ▸ | PDK2 | Q15119 | 3/20 | 0.44 |
| ▸ | PDK3 | Q15120 | 3/20 | 0.44 |
| ▸ | PDK4 | Q16654 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24529070 | 0.85 | TSHR (0.53) | HSD17B10MAPTTSHRTP53SMN1; SMN2 | |
| SCHEMBL2087233 | 0.75 | SMN1; SMN2 (0.62) | TSHRSMN1; SMN2ALDH1A1MAPK1KDM4E | |
| SCHEMBL30369541 | 0.71 | TSHR (0.56) | HSD17B10MAPTTSHRTP53SMN1; SMN2 | |
| SCHEMBL22075949 | 0.71 | TSHR (0.56) | HSD17B10MAPTTSHRTP53SMN1; SMN2 | |
| SCHEMBL22075942 | 0.71 | TSHR (0.56) | HSD17B10MAPTTSHRTP53SMN1; SMN2 | |
| SCHEMBL29040439 | 0.71 | MAPT (0.52) | HSD17B10MAPTTSHRTP53SMN1; SMN2 | |
| SCHEMBL30457845 | 0.71 | MAPT (0.52) | HSD17B10MAPTTSHRTP53SMN1; SMN2 | |
| SCHEMBL23499609 | 0.70 | ALDH1A1 (0.55) | HSD17B10MAPTTSHRTP53SMN1; SMN2 | |
| SCHEMBL30457737 | 0.70 | PDK1 (0.64) | HSD17B10MAPTTSHRTP53SMN1; SMN2 | |
| SCHEMBL30457883 | 0.70 | ALDH1A1 (0.52) | HSD17B10MAPTTSHRTP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022129925-A1 | NOVEL BIFUNCTIONAL MOLECULES FOR TARGETED PROTEIN DEGRADATION | AMPHISTA THERAPEUTICS LIMITED (GB) | 2022-06-23 | — | — | WO | disclosed |