Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | TP53 | P04637 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | PDK1 | Q15118 | 3/20 | 0.49 |
| ▸ | PDK2 | Q15119 | 3/20 | 0.49 |
| ▸ | PDK3 | Q15120 | 3/20 | 0.49 |
| ▸ | PDK4 | Q16654 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22075942 | 0.86 | TSHR (0.56) | TSHRHSD17B10ALOX15MAPTTP53 | |
| SCHEMBL22075949 | 0.86 | TSHR (0.56) | TSHRHSD17B10ALOX15MAPTTP53 | |
| SCHEMBL30369541 | 0.86 | TSHR (0.56) | TSHRHSD17B10ALOX15MAPTTP53 | |
| SCHEMBL24529066 | 0.85 | HSD17B10 (0.46) | TSHRHSD17B10MAPTTP53NPC1 | |
| SCHEMBL23499609 | 0.85 | ALDH1A1 (0.55) | TSHRHSD17B10ALOX15MAPTTP53 | |
| SCHEMBL29040439 | 0.76 | MAPT (0.52) | TSHRHSD17B10ALOX15MAPTTP53 | |
| SCHEMBL30457845 | 0.76 | MAPT (0.52) | TSHRHSD17B10ALOX15MAPTTP53 | |
| SCHEMBL2087233 | 0.76 | SMN1; SMN2 (0.62) | TSHRSMN1; SMN2ALDH1A1KDM4EMAPK1 | |
| SCHEMBL30457883 | 0.75 | ALDH1A1 (0.52) | TSHRHSD17B10MAPTTP53NPC1 | |
| SCHEMBL30457882 | 0.75 | PDK1 (0.64) | TSHRHSD17B10MAPTTP53NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240115711-A1 | Novel Bifunctional Molecules For Targeted Protein Degradation | AMPHISTA THERAPEUTICS LIMITED (GB) | 2024-04-11 | — | — | US | disclosed |
| CN-116897150-A | Novel bifunctional molecules for protein-targeted degradation | 安菲斯塔治疗有限公司 | 2023-10-17 | — | — | CN | disclosed |
| WO-2022129925-A1 | NOVEL BIFUNCTIONAL MOLECULES FOR TARGETED PROTEIN DEGRADATION | AMPHISTA THERAPEUTICS LIMITED (GB) | 2022-06-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240115711-A1 | Novel Bifunctional Molecules For Targeted Protein Degradation | PSMG3, MYCBP2, PSME2 | TSHR 3727/4885HSD17B10 3039/4885ALOX15 4517/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.