Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRIM33 | Q9UPN9 | 4/20 | 0.41 |
| ▸ | AXL | P30530 | 2/20 | 0.40 |
| ▸ | FLT3 | P36888 | 2/20 | 0.40 |
| ▸ | MERTK | Q12866 | 2/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.38 |
| ▸ | CASR | P41180 | 4/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24529175 | 0.86 | TRIM33 (0.39) | TRIM33AXLFLT3MERTKGRM2 | |
| SCHEMBL27181397 | 0.86 | TRIM33 (0.39) | TRIM33AXLFLT3MERTKGRM2 | |
| SCHEMBL3920300 | 0.81 | CASR (0.59) | TRIM33AXLFLT3MERTKCASR | |
| SCHEMBL24529531 | 0.79 | HCRTR2 (0.52) | AXLFLT3MERTKDYRK1ATGFBR1 | |
| SCHEMBL27179772 | 0.79 | HCRTR2 (0.52) | AXLFLT3MERTKDYRK1ATGFBR1 | |
| SCHEMBL24529202 | 0.78 | TRIM33 (0.46) | TRIM33AXLFLT3MERTKDYRK1A | |
| SCHEMBL3920376 | 0.73 | TRIM33 (0.44) | TRIM33AXLFLT3MERTKCASR | |
| SCHEMBL27181434 | 0.72 | SYK (0.39) | CASR | |
| SCHEMBL24529318 | 0.72 | SYK (0.39) | CASR | |
| SCHEMBL31380975 | 0.71 | ALDH1A3 (0.56) | TRIM33AXLFLT3MERTKDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022132696-A1 | UREA OREXIN RECEPTOR AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2022-06-23 | — | — | WO | disclosed |