SCHEMBL31380975

SCHEMBL31380975

COc1ccc(-c2ccc3nccn3c2)cc1OC

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A3 P47895 1/20 0.56
▸ DYRK1A Q13627 2/20 0.55
▸ TRIM33 Q9UPN9 4/20 0.50
▸ RAB9A P51151 4/20 0.50
▸ SMN1; SMN2 Q16637 4/20 0.50
▸ KDM4E B2RXH2 3/20 0.50
▸ ALDH1A1 P00352 3/20 0.50
▸ HPGD P15428 3/20 0.50
▸ HSD17B10 Q99714 3/20 0.50
▸ NPC1 O15118 2/20 0.50
▸ TP53 P04637 2/20 0.50
▸ PKM P14618 2/20 0.50
▸ MAPK1 P28482 2/20 0.50
▸ TSHR P16473 2/20 0.50
▸ MAPT P10636 3/20 0.48
▸ ALOX15 P16050 1/20 0.48
▸ NFKB1 P19838 1/20 0.48
▸ HTT P42858 1/20 0.48
▸ NFKB2 Q00653 1/20 0.48
▸ RELA Q04206 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31380900 0.83 ALDH1A1 (0.45) ALDH1A3DYRK1ARAB9ASMN1; SMN2KDM4E
SCHEMBL13336394 0.79 ALDH1A3 (0.53) ALDH1A3DYRK1ATRIM33PIK3CGNAMPT
SCHEMBL14826052 0.78 DYRK1A (0.85) DYRK1AHPGDHSD17B10NFKB1PIK3CA
SCHEMBL7606528 0.78 DYRK1A (0.42) ALDH1A3DYRK1ATRIM33PIK3CDAXL
SCHEMBL15743365 0.76 DYRK1A (0.55) DYRK1ATRIM33JAK2FYNPDGFRB
SCHEMBL13680666 0.74 TGFBR1 (0.68) ALDH1A3DYRK1AHPGDHSD17B10NFKB1
SCHEMBL2535842 0.73 DYRK1A (0.55) DYRK1AHPGDHSD17B10NFKB1PIK3CA
SCHEMBL24529202 0.73 TRIM33 (0.46) DYRK1ATRIM33NAMPTAXLFLT3
SCHEMBL8840880 0.72 PDE4A (0.67) RAB9ASMN1; SMN2KDM4EALDH1A1HPGD
SCHEMBL18584820 0.72 DYRK1A (1.00) DYRK1AMAPTPIK3CAAXLFLT3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260070905-A1 Derivatives of Imidazo[1,2-A]Pyridine with Anti-Inflammatory Activity UNIV DE VELENCIA (ES) 2026-03-12 — — US claimed
WO-2025003545-A1 DERIVATIVES OF IMIDAZO[1,2-A]PYRIDINE WITH ANTI-INFLAMMATORY ACTIVITY UNIVERSITAT DE VALÈNCIA (ES) 2025-01-02 — — WO claimed
US-20260070905-A1 Derivatives of Imidazo[1,2-A]Pyridine with Anti-Inflammatory Activity UNIV DE VELENCIA (ES) 2026-03-12 — — US disclosed
WO-2025003545-A1 DERIVATIVES OF IMIDAZO[1,2-A]PYRIDINE WITH ANTI-INFLAMMATORY ACTIVITY UNIVERSITAT DE VALÈNCIA (ES) 2025-01-02 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260070905-A1 Derivatives of Imidazo[1,2-A]Pyridine with Anti-Inflammatory Activity IL1A, IL6, IL1B ALDH1A3 709/4885DYRK1A 4627/4885TRIM33 3251/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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