⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24529294 | 0.80 | PGK1 (0.31) | — | |
| SCHEMBL24529430 | 0.80 | PGK1 (0.35) | — | |
| SCHEMBL24529352 | 0.76 | CNR2 (0.31) | — | |
| SCHEMBL24529241 | 0.76 | S100A9 (0.35) | — | |
| SCHEMBL29723691 | 0.73 | HTR2A (0.34) | — | |
| SCHEMBL24529225 | 0.73 | HTR2A (0.34) | — | |
| SCHEMBL22094031 | 0.70 | ALDH1A1 (0.38) | — | |
| SCHEMBL26650250 | 0.70 | GBA1 (0.37) | — | |
| SCHEMBL26650249 | 0.70 | GBA1 (0.37) | — | |
| SCHEMBL24529521 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4262788-B1 | UREA OREXIN RECEPTOR AGONISTS | MERCK SHARP & DOHME LLC (US) | 2026-01-21 | — | — | EP | disclosed |
| US-20240101555-A1 | UREA OREXIN RECEPTOR AGONISTS | MERCK SHARP & DOHME LLC (US) | 2024-03-28 | — | — | US | disclosed |
| WO-2022132696-A1 | UREA OREXIN RECEPTOR AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2022-06-23 | — | — | WO | disclosed |