Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.34 |
| ▸ | TNF | P01375 | 3/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2453112 | 0.86 | KMT2A (0.49) | KMT2AATMALDH1A1PKMSLC1A2 | |
| SCHEMBL15511368 | 0.82 | CA1 (0.41) | KMT2AATMALDH1A1PKMSLC1A2 | |
| SCHEMBL1251744 | 0.81 | ALDH1A1 (0.41) | KMT2AATMALDH1A1PKMBRD4 | |
| SCHEMBL2458117 | 0.76 | MAPT (0.46) | KMT2AATMALDH1A1PKMMAPT | |
| SCHEMBL1251745 | 0.74 | ALDH1A1 (0.41) | KMT2AATMALDH1A1PKMSLC1A2 | |
| SCHEMBL17706710 | 0.74 | L3MBTL1 (0.43) | KMT2AALDH1A1MAPTRAB9ATSHR | |
| SCHEMBL11567612 | 0.74 | L3MBTL1 (0.43) | KMT2AALDH1A1MAPTRAB9ATSHR | |
| SCHEMBL28918361 | 0.73 | MAPT (0.38) | KMT2AATMALDH1A1PKMMAPT | |
| SCHEMBL9650037 | 0.73 | ALDH1A1 (0.70) | KMT2AATMALDH1A1PKMSLC1A2 | |
| SCHEMBL43936 | 0.72 | ALDH1A1 (0.49) | KMT2AATMALDH1A1PKMSLC1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2955233-A1 | Proteinase K inhibitors, methods and compositions therefor | Life Technologies Corporation (US) | 2015-12-16 | — | — | EP | disclosed |
| US-9114104-B2 | Proteinase K inhibitors, methods and compositions therefor | Life Technologies Corporation (US) | 2015-08-25 | — | — | US | disclosed |
| EP-2367954-B1 | PROTEINASE K INHIBITORS, METHODS AND COMPOSITIONS THEREFOR | LIFE TECHNOLOGIES CORP (US) | 2015-02-18 | — | — | EP | disclosed |
| US-20130004941-A1 | PROTEINASE K INHIBITORS, METHODS AND COMPOSITIONS THEREFOR | Life Technologies Corporation (US) | 2013-01-03 | — | — | US | disclosed |
| US-8211637-B2 | Proteinase K inhibitors, methods and compositions therefor | Life Technologies Corporation (US) | 2012-07-03 | — | — | US | disclosed |
| EP-2367954-A1 | PROTEINASE K INHIBITORS, METHODS AND COMPOSITIONS THEREFOR | Life Technologies Corporation (US) | 2011-09-28 | — | — | EP | disclosed |
| WO-2010071833-A1 | PROTEINASE K INHIBITORS, METHODS AND COMPOSITIONS THEREFOR | Life Technologies Corporation (US) | 2010-06-24 | — | — | WO | disclosed |
| US-20100159482-A1 | PROTEINASE K INHIBITORS, METHODS AND COMPOSITIONS THEREFOR | Life Technologies Corporation (US) | 2010-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130004941-A1 | PROTEINASE K INHIBITORS, METHODS AND COMPOSITIONS THEREFOR | CPSF7, CTSL, CTSK | KMT2A 1951/4885ATM 3957/4885ALDH1A1 3836/4885 |
| US-20100159482-A1 | PROTEINASE K INHIBITORS, METHODS AND COMPOSITIONS THEREFOR | CPSF7, CTSL, CTSK | KMT2A 1951/4885ATM 3957/4885ALDH1A1 3836/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.