Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.51 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 2/20 | 0.42 |
| ▸ | CES1 | P23141 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL366066 | 1.00 | LMNA (0.62) | LMNAMAPK1KEAP1NFE2L2BLM | |
| SCHEMBL245404 | 1.00 | LMNA (0.62) | LMNAMAPK1KEAP1NFE2L2BLM | |
| SCHEMBL11835765 | 0.94 | LMNA (0.56) | LMNAMAPK1KEAP1NFE2L2BLM | |
| D-Alanine SCHEMBL11208357 | 0.90 | LMNA (0.52) | LMNAMAPK1KEAP1NFE2L2BLM | |
| D-Alanine SCHEMBL11207612 | 0.90 | LMNA (0.52) | LMNAMAPK1KEAP1NFE2L2BLM | |
| Alanine SCHEMBL11209772 | 0.90 | LMNA (0.52) | LMNAMAPK1KEAP1NFE2L2BLM | |
| Alanine SCHEMBL11204313 | 0.90 | LMNA (0.52) | LMNAMAPK1KEAP1NFE2L2BLM | |
| D-Alanine SCHEMBL11496478 | 0.88 | LMNA (0.50) | LMNAMAPK1KEAP1NFE2L2BLM | |
| SCHEMBL275597 | 0.87 | LMNA (0.79) | LMNAMAPK1BLMNPSR1TSHR | |
| SCHEMBL9000789 | 0.81 | LMNA (0.62) | LMNAMAPK1BLMNPSR1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 205 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113355367-B | Application of ketoacid reductase in synthesis of chiral aromatic 2-hydroxy acid | 浙江工业大学 | 2024-03-26 | — | — | CN | claimed |
| US-20220281839-A1 | BENZIMIDAZOLE DERIVATIVES AS DUAL HISTAMINE H1 AND HISTAMINE H4 RECEPTOR LIGANDS | BIOPROJET SOC CIV (FR) | 2022-09-08 | — | — | US | claimed |
| CN-113355299-B | Ketoacid reductase, gene, engineering bacterium and application in synthesis of chiral aromatic 2-hydroxy acid | 浙江工业大学 | 2022-05-24 | — | — | CN | claimed |
| US-11306069-B2 | Benzimidazole derivatives as dual histamine H1 and histamine H4 receptor ligands | BIOPROJET (FR) | 2022-04-19 | — | — | US | claimed |
| CN-113355299-A | Ketoacid reductase, gene, engineering bacterium and application in synthesis of chiral aromatic 2-hydroxy acid | 浙江工业大学 | 2021-09-07 | — | — | CN | claimed |
| CN-113355367-A | Application of ketoacid reductase in synthesis of chiral aromatic 2-hydroxy acid | 浙江工业大学 | 2021-09-07 | — | — | CN | claimed |
| CN-108410831-B | Ketoacid reductase, gene, engineering bacterium and application in synthesis of chiral aromatic 2-hydroxy acid | 浙江工业大学 | 2021-07-27 | — | — | CN | claimed |
| EP-3486243-B1 | BENZIMIDAZOLE DERIVATIVES AS DUAL HISTAMINE H1 AND HISTAMINE H4 RECEPTOR LIGANDS | BIOPROJET SOC CIV (FR) | 2020-04-15 | — | — | EP | claimed |
| CN-107339183-B | Fuel injector for internal combustion engine | 通用汽车环球科技运作有限责任公司 | 2019-10-22 | — | — | CN | claimed |
| EP-3486243-A1 | BENZIMIDAZOLE DERIVATIVES AS DUAL HISTAMINE H1 AND HISTAMINE H4 RECEPTOR LIGANDS | Bioprojet (FR) | 2019-05-22 | — | — | EP | claimed |
| CN-107339183-A | Fuel injector for explosive motor | 通用汽车环球科技运作有限责任公司 | 2017-11-10 | — | — | CN | claimed |
| CN-102660471-B | Production of chiral alpha-hydroxy acid and its strain by using biological catalysis method | UNIV ZHEJIANG TECHNOLOGY | 2014-11-05 | — | — | CN | claimed |
| CN-102660470-B | Sinorhizobium fredii and its application in producing chiral alpha-hydroxy acid by biologically splitting alpha-hydroxy acid raceme | UNIV ZHEJIANG TECHNOLOGY | 2013-07-31 | — | — | CN | claimed |
| CN-102660471-A | Production of chiral alpha-hydroxy acid and its strain by using biological catalysis method | UNIV ZHEJIANG TECHNOLOGY | 2012-09-12 | — | — | CN | claimed |
| CN-102660470-A | Sinorhizobium fredii and its application in producing chiral alpha-hydroxy acid by biologically splitting alpha-hydroxy acid raceme | UNIV ZHEJIANG TECHNOLOGY | 2012-09-12 | — | — | CN | claimed |
| US-7985572-B2 | Modified nitrilases and their use in methods for the production of carboxylic acids | BASF SE (DE) | 2011-07-26 | — | — | US | claimed |
| CN-101911914-A | Culture medium for spore germination and seedling culturing of pteridophyte | UNIV CHINA GEOSCIENCES WUHAN | 2010-12-15 | — | — | CN | claimed |
| EP-1599584-B1 | MODIFIED NITRILASES AND THEIR USE IN METHODS FOR THE PRODUCTION OF CARBOXYLIC ACIDS | BASF SE (DE) | 2009-07-01 | — | — | EP | claimed |
| US-20070112216-A1 | Method for producing chiral mercapto amino acids | DSM FINE CHEMICALS AUSTRIA NFG GMBH & CO KG (AT) | 2007-05-17 | — | — | US | claimed |
| US-20060259999-A1 | Modified nitrilases and their use in methods for the production of carboxylic acids | BASF AKTIENGESELLSCHAFT (DE) | 2006-11-16 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070112216-A1 | Method for producing chiral mercapto amino acids | CPN1, AKR1C3, AHCY | LMNA 1994/4885MAPK1 2896/4885KEAP1 1368/4885 |
| US-20220281839-A1 | BENZIMIDAZOLE DERIVATIVES AS DUAL HISTAMINE H1 AND HISTAMINE H4 RECEPTOR LIGANDS | HRH4, HRH3, HRH1 | LMNA 4626/4885MAPK1 3796/4885KEAP1 1128/4885 |
| US-11306069-B2 | Benzimidazole derivatives as dual histamine H1 and histamine H4 receptor ligands | HRH4, HRH3, HRH1 | LMNA 4746/4885MAPK1 3692/4885KEAP1 1280/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.