Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | PRKACA | P17612 | 1/20 | 0.36 |
| ▸ | PRKACG | P22612 | 1/20 | 0.36 |
| ▸ | PRKACB | P22694 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | GPR174 | Q9BXC1 | 1/20 | 0.33 |
| ▸ | ATR | Q13535 | 1/20 | 0.32 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.32 |
| ▸ | MAT2A | P31153 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17525158 | 0.80 | PRKACA (0.39) | PRKACAPRKACGPRKACBCTSKATR | |
| SCHEMBL24309493 | 0.80 | GID4 (0.41) | KMT2AMEN1PRKACAPRKACGPRKACB | |
| SCHEMBL19580550 | 0.79 | NISCH (0.40) | KMT2AMEN1PRKACAPRKACGPRKACB | |
| SCHEMBL19580707 | 0.79 | NISCH (0.40) | KMT2AMEN1PRKACAPRKACGPRKACB | |
| Hydrochloric Acid SCHEMBL27174165 | 0.78 | NISCH (0.39) | KMT2AMEN1PRKACAPRKACGPRKACB | |
| Hydrochloric Acid SCHEMBL29650845 | 0.78 | NISCH (0.39) | KMT2AMEN1PRKACAPRKACGPRKACB | |
| SCHEMBL18387 | 0.77 | CSNK1D (0.43) | PRKACAPRKACGPRKACBCTSKACVR1 | |
| SCHEMBL280628 | 0.77 | CSNK1D (0.43) | PRKACAPRKACGPRKACBCTSKACVR1 | |
| SCHEMBL8321907 | 0.77 | CSNK1D (0.43) | PRKACAPRKACGPRKACBCTSKACVR1 | |
| SCHEMBL14839568 | 0.77 | KCNH2 (0.43) | KMT2APRKACAPRKACGPRKACBGABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220194955-A1 | NOVEL PRMT5 INHIBITORS | AMGEN INC. (US) | 2022-06-23 | — | — | US | disclosed |
| WO-2022132914-A1 | PRMTS INHIBITORS | AMGEN INC. (US) | 2022-06-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220194955-A1 | NOVEL PRMT5 INHIBITORS | PRMT5, PRMT1, PRMT6 | KMT2A 47/4885MEN1 997/4885NPC1 2774/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.