Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | EDNRA | P25101 | 1/20 | 0.37 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24549597 | 0.81 | SLC40A1 (0.47) | ALDH1A1POLBMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL427939 | 0.80 | CA12 (0.52) | ALDH1A1POLBMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL14247776 | 0.79 | ALDH1A1 (0.41) | ALDH1A1MEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL21633890 | 0.77 | POLB (0.44) | ALDH1A1POLBMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL21885975 | 0.76 | CHRM2 (0.43) | ALDH1A1POLBMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2645976 | 0.74 | NFE2L2 (0.41) | POLBMEN1KMT2AKDM4EPTK2 | |
| SCHEMBL4781214 | 0.72 | CA1 (0.61) | ALDH1A1MEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL8688550 | 0.71 | L3MBTL1 (0.56) | ALDH1A1POLBMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL1465207 | 0.71 | NFE2L2 (0.42) | ALDH1A1POLBMEN1KMT2ASMN1; SMN2 | |
| Fluoride SCHEMBL30882857 | 0.71 | CA1 (0.59) | ALDH1A1MEN1KMT2ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220194945-A1 | Imidazolopyridine Compounds For IRE1 Inhibition | Optikira, LLC | 2022-06-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220194945-A1 | Imidazolopyridine Compounds For IRE1 Inhibition | XBP1, ERN2, ERN1 | ALDH1A1 2541/4885MAPK10 1320/4885POLB 3535/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.