Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | FLT4 | P35916 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.35 |
| ▸ | TEK | Q02763 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23538115 | 0.82 | POLB (0.52) | POLBTDP1L3MBTL1ALDH1A1NPC1 | |
| SCHEMBL15546774 | 0.76 | POLB (0.39) | POLBTDP1L3MBTL1ALDH1A1NPC1 | |
| SCHEMBL31521561 | 0.76 | DGAT1 (0.36) | POLBL3MBTL1NPC1LMNAHTT | |
| SCHEMBL23551437 | 0.72 | ALDH1A1 (0.54) | POLBTDP1L3MBTL1ALDH1A1NPC1 | |
| SCHEMBL1049931 | 0.71 | KRAS (0.41) | POLBTDP1L3MBTL1ALDH1A1NPC1 | |
| SCHEMBL13057796 | 0.71 | EGFR (0.39) | POLBTDP1L3MBTL1ALDH1A1NPC1 | |
| SCHEMBL23855061 | 0.70 | NPC1 (0.40) | POLBALDH1A1NPC1MAPTRAB9A | |
| SCHEMBL23855046 | 0.70 | ALDH1A1 (0.45) | POLBALDH1A1NPC1MAPTRAB9A | |
| SCHEMBL23551502 | 0.70 | CNR2 (0.40) | ALDH1A1NPC1MAPTRAB9AHPGD | |
| SCHEMBL17100403 | 0.68 | POLB (0.38) | POLBTDP1L3MBTL1ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022133480-A1 | ARYL HYDROCARBON RECEPTOR (AHR) AGONISTS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-06-23 | — | — | WO | disclosed |
| WO-2022133480-A1 | ARYL HYDROCARBON RECEPTOR (AHR) AGONISTS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-06-23 | — | — | WO | disclosed |