Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 10/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | F2RL3 | Q96RI0 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | F2 | P00734 | 1/20 | 0.45 |
| ▸ | PLAU | P00749 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2730918 | 0.82 | GAA (0.48) | ELANEL3MBTL1ALDH1A1F2RL3MAPT | |
| SCHEMBL7673745 | 0.79 | EGFR (0.42) | ELANEL3MBTL1ALDH1A1KDM4EMAPT | |
| SCHEMBL1056622 | 0.76 | ALDH1A1 (0.74) | L3MBTL1ALDH1A1KDM4EGAATSHR | |
| SCHEMBL29350132 | 0.76 | ALDH1A1 (0.74) | L3MBTL1ALDH1A1KDM4EGAATSHR | |
| SCHEMBL9038399 | 0.76 | CCR2 (0.51) | L3MBTL1ALDH1A1KDM4EMAPTMEN1 | |
| SCHEMBL2730661 | 0.76 | GAA (0.47) | ELANEL3MBTL1ALDH1A1F2RL3MAPT | |
| SCHEMBL2730721 | 0.76 | RECQL (0.49) | ELANEL3MBTL1ALDH1A1KDM4EMAPT | |
| SCHEMBL30639225 | 0.76 | TSHR (0.66) | ELANEL3MBTL1ALDH1A1KDM4EMAPT | |
| SCHEMBL7878088 | 0.76 | TSHR (0.66) | ELANEL3MBTL1ALDH1A1KDM4EMAPT | |
| SCHEMBL9867870 | 0.75 | ALDH1A1 (0.68) | ELANEL3MBTL1ALDH1A1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2367817-A1 | INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE | Via Pharmaceuticals, Inc. (US) | 2011-09-28 | — | — | EP | disclosed |
| WO-2010065310-A1 | INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE | VIA PHARMACEUTICALS, INC (US) | 2010-06-10 | — | — | WO | disclosed |