Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.41 |
| ▸ | BCL2 | P10415 | 1/20 | 0.41 |
| ▸ | RORC | P51449 | 2/20 | 0.40 |
| ▸ | FOLH1 | Q04609 | 3/20 | 0.40 |
| ▸ | EGFR | P00533 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9272720 | 0.98 | CCR2 (0.50) | CCR2KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL7673745 | 0.85 | EGFR (0.42) | CCR2KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL7482958 | 0.84 | MCL1 (0.52) | CCR2KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL27505802 | 0.80 | KDM4E (0.53) | KDM4EALDH1A1MEN1KMT2APOLB | |
| SCHEMBL28341246 | 0.80 | KDM4E (0.42) | CCR2KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL14126895 | 0.77 | EGFR (0.41) | CCR2KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL2455488 | 0.76 | ELANE (0.53) | KDM4EALDH1A1MEN1KMT2AL3MBTL1 | |
| SCHEMBL4119321 | 0.74 | ACLY (0.51) | CCR2MEN1KMT2ALMNASRC | |
| SCHEMBL16975852 | 0.73 | KMT2A (0.57) | KDM4EALDH1A1MEN1KMT2APOLB | |
| SCHEMBL2731589 | 0.71 | FOLH1 (0.46) | CCR2KDM4EALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0723541-A1 | INDOLE DERIVATIVES AS NMDA ANTAGONISTS | GLAXO WELLCOME S.p.A. (IT) | 1996-07-31 | — | — | EP | disclosed |
| WO-1995010517-A1 | INDOLE DERIVATIVES AS NMDA ANTAGONISTS | GLAXO WELLCOME S.P.A. (IT) | 1995-04-20 | — | — | WO | disclosed |