Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | ATM | Q13315 | 2/20 | 0.42 |
| ▸ | CCR2 | P41597 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | XBP1 | P17861 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9038399 | 0.85 | CCR2 (0.51) | EGFRSRCKMT2AATMCCR2 | |
| SCHEMBL9272720 | 0.84 | CCR2 (0.50) | EGFRSRCKMT2AATMCCR2 | |
| SCHEMBL28208613 | 0.80 | TSHR (0.51) | EGFRSRCKMT2AKDM4EF10 | |
| SCHEMBL2455488 | 0.79 | ELANE (0.53) | KMT2AKDM4EF2ALDH1A1MAPT | |
| SCHEMBL2730314 | 0.73 | CCR2 (0.41) | CCR2F2F10PARP1 | |
| SCHEMBL28341246 | 0.73 | KDM4E (0.42) | EGFRSRCKMT2ACCR2KDM4E | |
| SCHEMBL7482958 | 0.73 | MCL1 (0.52) | EGFRKMT2AATMCCR2KDM4E | |
| SCHEMBL16975852 | 0.73 | KMT2A (0.57) | EGFRSRCKMT2AATMKDM4E | |
| SCHEMBL4601826 | 0.73 | HTR6 (0.41) | EGFRSRCKDM4EALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL2731134 | 0.72 | CCR2 (0.41) | KMT2ACCR2F2F10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6414013-B1 | KINASE INHIBITORS; ANTICANCER AGENTS | PHARMACIA & UPJOHN S.P.A. (IT) | 2002-07-02 | — | — | US | disclosed |