Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALKBH3 | Q96Q83 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CCR2 | P41597 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ENPP1 | P22413 | 7/20 | 0.37 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2455657 | 0.86 | ENPP1 (0.50) | ALKBH3CCR2ENPP1NR3C1 | |
| SCHEMBL12858718 | 0.85 | KDM4E (0.48) | ALKBH3POLBMAPTHPGDL3MBTL1 | |
| SCHEMBL2460016 | 0.83 | CCR2 (0.36) | ALKBH3POLBMAPTCCR2USP2 | |
| SCHEMBL2460011 | 0.81 | CCR2 (0.43) | POLBMAPTCCR2HPGDTSHR | |
| SCHEMBL2456787 | 0.80 | CCR2 (0.43) | ALKBH3POLBMAPTCCR2USP2 | |
| SCHEMBL2464506 | 0.75 | MBOAT4 (0.40) | ALKBH3PDE2A | |
| SCHEMBL20074286 | 0.74 | ALDH1A1 (0.46) | MAPTHPGDTSHRKDM4E | |
| SCHEMBL2459450 | 0.74 | ENPP1 (0.47) | ALKBH3CCR2ENPP1 | |
| SCHEMBL2457283 | 0.73 | ENPP1 (0.46) | ALKBH3CCR2ENPP1NR3C1 | |
| SCHEMBL2461260 | 0.72 | CCR2 (0.48) | ALKBH3CCR2ENPP1NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011114148-A1 | 4H- [1, 2, 4] TRIAZOLO [5, 1 -B] PYRIMIDIN-7 -ONE DERIVATIVES AS CCR2B RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2011-09-22 | — | — | WO | claimed |
| WO-2011114148-A1 | 4H- [1, 2, 4] TRIAZOLO [5, 1 -B] PYRIMIDIN-7 -ONE DERIVATIVES AS CCR2B RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2011-09-22 | — | — | WO | disclosed |
| WO-2011114148-A1 | 4H- [1, 2, 4] TRIAZOLO [5, 1 -B] PYRIMIDIN-7 -ONE DERIVATIVES AS CCR2B RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2011-09-22 | — | — | WO | disclosed |