Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.48 |
| ▸ | ALKBH3 | Q96Q83 | 6/20 | 0.44 |
| ▸ | ENPP1 | P22413 | 3/20 | 0.44 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | IDH1 | O75874 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | FPR1 | P21462 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2465378 | 0.85 | ALKBH3 (0.41) | KDM4EALKBH3ENPP1HPGDPOLB | |
| SCHEMBL2455657 | 0.85 | ENPP1 (0.50) | ALKBH3ENPP1ALDH1A1SMN1; SMN2 | |
| SCHEMBL20074286 | 0.80 | ALDH1A1 (0.46) | KDM4EALDH1A1SMN1; SMN2HPGDTDP1 | |
| SCHEMBL2424398 | 0.78 | KDM4E (0.47) | KDM4EALKBH3KAT8ALDH1A1SMN1; SMN2 | |
| SCHEMBL2425276 | 0.76 | KDM4E (0.46) | KDM4EALKBH3KAT8ALDH1A1SMN1; SMN2 | |
| SCHEMBL11714380 | 0.76 | GAA (0.40) | KDM4EALDH1A1TDP1MAPTL3MBTL1 | |
| SCHEMBL2464506 | 0.76 | MBOAT4 (0.40) | ALKBH3 | |
| SCHEMBL20074185 | 0.72 | ALDH1A1 (0.44) | KDM4EALKBH3ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL23335792 | 0.72 | KDM4E (0.76) | KDM4EALKBH3ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL2459450 | 0.72 | ENPP1 (0.47) | ALKBH3ENPP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110028719-A1 | SCREENING METHODS FOR AMYLOID BETA MODULATORS | WARATAH PHARMACEUTICALS INC. (CA) | 2011-02-03 | — | — | US | disclosed |
| US-20110028719-A1 | SCREENING METHODS FOR AMYLOID BETA MODULATORS | WARATAH PHARMACEUTICALS INC. (CA) | 2011-02-03 | — | — | US | disclosed |
| WO-2007134449-A1 | SCREENING METHODS FOR AMYLOID BETA MODULATORS | WARATAH PHARMACEUTICALS INC. (CA) | 2007-11-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110028719-A1 | SCREENING METHODS FOR AMYLOID BETA MODULATORS | APP, BACE1, IAPP | KDM4E 4738/4885ALKBH3 4748/4885ENPP1 1719/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.