Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 2/20 | 0.37 |
| ▸ | DHFR | P00374 | 1/20 | 0.34 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.31 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.31 |
| ▸ | DHODH | Q02127 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.30 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.30 |
| ▸ | ESR1 | P03372 | 1/20 | 0.30 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL245573 | 1.00 | MCHR1 (0.37) | MCHR1DHFRPSIP1ERAP1DHODH | |
| SCHEMBL15186248 | 0.90 | MCHR1 (0.36) | MCHR1DHFR | |
| SCHEMBL245498 | 0.89 | CRHR1 (0.33) | MCHR1PSIP1CYP3A4CRHR1 | |
| SCHEMBL245497 | 0.89 | CRHR1 (0.33) | MCHR1PSIP1CYP3A4CRHR1 | |
| SCHEMBL241637 | 0.88 | MCHR1 (0.36) | MCHR1DHFRPSIP1DHODHCYP3A4 | |
| SCHEMBL241636 | 0.88 | MCHR1 (0.36) | MCHR1DHFRPSIP1DHODHCYP3A4 | |
| SCHEMBL241635 | 0.88 | MCHR1 (0.36) | MCHR1DHFRPSIP1DHODHCYP3A4 | |
| SCHEMBL15182608 | 0.87 | MCHR1 (0.37) | MCHR1DHFRPSIP1DHODHCYP3A4 | |
| SCHEMBL244061 | 0.87 | PSIP1 (0.43) | MCHR1DHFRPSIP1DHODHCYP3A4 | |
| SCHEMBL244600 | 0.87 | PSIP1 (0.43) | MCHR1DHFRPSIP1DHODHCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588455-B1 | 2-QUINOLINYL-ACETIC ACID DERIVATIVES AS HIV ANTIVIRAL COMPOUNDS | GILEAD SCIENCES INC (US) | 2018-04-04 | — | — | EP | disclosed |
| US-9296758-B2 | 2-quinolinyl-acetic acid derivatives as HIV antiviral compounds | GILEAD SCIENCES, INC. (US) | 2016-03-29 | — | — | US | disclosed |
| US-20130210801-A1 | 2-QUINOLINYL-ACETIC ACID DERIVATIVES AS HIV ANTIVIRAL COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2013-08-15 | — | — | US | disclosed |
| CN-103209963-A | 2-quinolinyl-acetic acid derivatives as HIV antiviral compounds | GILEAD SCIENCES INC | 2013-07-17 | — | — | CN | disclosed |
| EP-2588455-A1 | 2 -QUINOLINYL- ACETIC ACID DERIVATIVES AS HIV ANTIVIRAL COMPOUNDS | Gilead Sciences, Inc. (US) | 2013-05-08 | — | — | EP | disclosed |
| WO-2012003498-A1 | 2 -QUINOLINYL- ACETIC ACID DERIVATIVES AS HIV ANTIVIRAL COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2012-01-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130210801-A1 | 2-QUINOLINYL-ACETIC ACID DERIVATIVES AS HIV ANTIVIRAL COMPOUNDS | NFATC1, ACIN1, ARF1 | MCHR1 2464/4885DHFR 647/4885PSIP1 3417/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.