Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.76 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.76 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.76 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.76 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.76 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.76 |
| ▸ | TSHR | P16473 | 1/20 | 0.76 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | CFTR | P13569 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8196979 | 0.87 | KDM4E (0.77) | ALDH1A1HSD17B10KDM4ECYP1A2CYP3A4 | |
| SCHEMBL8192931 | 0.87 | ALDH1A1 (0.57) | ALDH1A1HSD17B10KDM4ECYP1A2CYP3A4 | |
| SCHEMBL29372580 | 0.86 | ALDH1A1 (1.00) | ALDH1A1HSD17B10KDM4ECYP1A2CYP3A4 | |
| SCHEMBL8313781 | 0.86 | KDM4E (0.76) | ALDH1A1HSD17B10KDM4ECYP1A2CYP3A4 | |
| SCHEMBL157252 | 0.86 | ALDH1A1 (1.00) | ALDH1A1HSD17B10KDM4ECYP1A2CYP3A4 | |
| SCHEMBL8192928 | 0.85 | ALDH1A1 (0.74) | ALDH1A1HSD17B10KDM4ECYP1A2CYP3A4 | |
| SCHEMBL8193398 | 0.83 | ALDH1A1 (0.53) | ALDH1A1HSD17B10KDM4ECYP1A2CYP3A4 | |
| SCHEMBL8224986 | 0.81 | KDM4E (0.69) | ALDH1A1HSD17B10KDM4ECYP1A2CYP3A4 | |
| SCHEMBL8193619 | 0.81 | ALDH1A1 (0.51) | ALDH1A1HSD17B10KDM4ECYP1A2CYP3A4 | |
| SCHEMBL8191842 | 0.80 | ALDH1A1 (0.83) | ALDH1A1HSD17B10KDM4ECYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6136810-A | DRUGS AS ENZYME INHIBITORS OF PHOSPHODIESTERASE | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2000-10-24 | — | — | US | claimed |
| EP-0885894-A1 | PYRIDO [2,3-D] PYRIMIDINE DERIVATIVES AND MEDICINAL COMPOSITIONS THEREOF | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1998-12-23 | — | — | EP | claimed |
| WO-2011146819-A2 | METHODS AND COMPOSITIONS FOR TREATMENT NF-κB-MEDIATED AND α7 INTEGRIN-SUPPRESSED DISEASES | DMD THERAPIES, LLC (US) | 2011-11-24 | — | — | WO | disclosed |
| US-20110224128-A1 | METHODS AND COMPOSITIONS FOR TREATMENT OF MUSCULAR DYSTROPHY | WHALEN ANNE | 2011-09-15 | — | — | US | disclosed |
| US-20060083714-A1 | Combination of a pde iv inhibitor and a tnf-alpha antagonist | PHARMACIA CORPORATION | 2006-04-20 | — | — | US | disclosed |
| US-6136810-A | DRUGS AS ENZYME INHIBITORS OF PHOSPHODIESTERASE | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2000-10-24 | — | — | US | disclosed |
| EP-0885894-A1 | PYRIDO [2,3-D] PYRIMIDINE DERIVATIVES AND MEDICINAL COMPOSITIONS THEREOF | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1998-12-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110224128-A1 | METHODS AND COMPOSITIONS FOR TREATMENT OF MUSCULAR DYSTROPHY | PYGM, TNNC1, MYOF | ALDH1A1 3179/4885HSD17B10 904/4885KDM4E 2360/4885 |
| US-20060083714-A1 | Combination of a pde iv inhibitor and a tnf-alpha antagonist | TNF, PDE4A, PDE3B | ALDH1A1 1288/4885HSD17B10 768/4885KDM4E 1546/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.