Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 5/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | ALPL | P05186 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 2/20 | 0.36 |
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2459809 | 0.78 | RAB9A (0.40) | RAB9ANPC1ALDH1A1LMNACHRM4 | |
| SCHEMBL2454974 | 0.74 | NPC1 (0.43) | RAB9ANPC1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL2454980 | 0.74 | EGFR (0.42) | RAB9ANPC1SMN1; SMN2LMNACHRM4 | |
| SCHEMBL2454948 | 0.73 | CNR1 (0.48) | GAARAB9ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL2460594 | 0.72 | ROCK2 (0.51) | NAMPTRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL2456117 | 0.72 | HPGD (0.46) | RAB9ANPC1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL2458764 | 0.71 | HDAC1 (0.48) | RAB9ANPC1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL2461640 | 0.70 | CNR2 (0.64) | RAB9ANPC1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL684122 | 0.70 | ATM (0.61) | ATMGAANAMPTRAB9ANPC1 | |
| SCHEMBL2456197 | 0.70 | PRKCI (0.45) | GAARAB9ANPC1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534277-B1 | ACYLATED, HETEROARYL-CONDENSED CYCLOALKENYLAMINES AND THEIR USE AS PHARMACEUTICALS | SANOFI AVENTIS DEUTSCHLAND (DE) | 2011-09-14 | — | — | EP | disclosed |
| EP-1534277-B1 | ACYLATED, HETEROARYL-CONDENSED CYCLOALKENYLAMINES AND THEIR USE AS PHARMACEUTICALS | SANOFI AVENTIS DEUTSCHLAND (DE) | 2011-09-14 | — | — | EP | disclosed |