Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 7/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.52 |
| ▸ | RAB9A | P51151 | 7/20 | 0.52 |
| ▸ | NPC1 | O15118 | 6/20 | 0.52 |
| ▸ | HPGD | P15428 | 4/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | CNR1 | P21554 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2460594 | 0.80 | ROCK2 (0.51) | SMN1; SMN2RAB9ANPC1HPGDMAPK1 | |
| SCHEMBL2454974 | 0.73 | NPC1 (0.43) | SMN1; SMN2RAB9ANPC1ALDH1A1MAPT | |
| SCHEMBL2463335 | 0.73 | CNR2 (0.64) | CNR2SMN1; SMN2RAB9ANPC1HPGD | |
| SCHEMBL2458242 | 0.71 | ALDH1A1 (0.56) | SMN1; SMN2HPGDALDH1A1MAPTLMNA | |
| SCHEMBL2456151 | 0.70 | ATM (0.42) | CNR2SMN1; SMN2RAB9ANPC1CNR1 | |
| SCHEMBL2459809 | 0.70 | RAB9A (0.40) | CNR2RAB9ANPC1CNR1ALDH1A1 | |
| SCHEMBL2458262 | 0.69 | RAB9A (0.57) | SMN1; SMN2RAB9ANPC1HPGDALDH1A1 | |
| SCHEMBL2456117 | 0.69 | HPGD (0.46) | SMN1; SMN2RAB9ANPC1HPGDTP53 | |
| SCHEMBL17949724 | 0.69 | RAB9A (0.82) | CNR2SMN1; SMN2RAB9ANPC1HPGD | |
| SCHEMBL2460515 | 0.69 | P2RX7 (0.62) | RAB9ANPC1LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534277-B1 | ACYLATED, HETEROARYL-CONDENSED CYCLOALKENYLAMINES AND THEIR USE AS PHARMACEUTICALS | SANOFI AVENTIS DEUTSCHLAND (DE) | 2011-09-14 | — | — | EP | disclosed |