Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 8/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.42 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1773002 | 0.81 | KIT (0.49) | KITDYRK1AMAP3K11 | |
| SCHEMBL25303525 | 0.81 | DYRK1A (0.50) | KITDYRK1AAAK1MAP3K11 | |
| SCHEMBL22049447 | 0.80 | CYP2C9 (0.36) | KITDYRK1ACYP2C9CYP3A4CYP2C19 | |
| SCHEMBL27920535 | 0.79 | SLC22A6 (0.45) | KITCYP2C9CYP3A4CYP2C19AAK1 | |
| SCHEMBL7921128 | 0.77 | MET (0.46) | CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL25839066 | 0.77 | KIT (0.41) | KITCYP2C9CYP3A4CYP2C19AAK1 | |
| SCHEMBL13199598 | 0.74 | CYP3A4 (0.44) | KITCYP2C9CYP3A4CYP2C19 | |
| SCHEMBL21902710 | 0.74 | CYP2C19 (0.40) | DYRK1ACYP2C9CYP3A4CYP2C19MAP3K11 | |
| SCHEMBL1045946 | 0.74 | BRD4 (0.54) | KITDYRK1ACYP2C9CYP3A4CYP2C19 | |
| SCHEMBL91445 | 0.74 | AXL (0.41) | CYP2C9CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023131122-A1 | FUSED RING-SUBSTITUTED SIX-MEMBERED HETEROCYCLIC COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 劲方医药科技(上海)有限公司 | 2023-07-13 | — | — | WO | disclosed |
| WO-2022140527-A1 | 6-HETEROARYLOXY BENZIMIDAZOLES AND AZABENZIMIDAZOLES AS JAK2 INHIBITORS | AJAX THERAPEUTICS, INC. (US) | 2022-06-30 | — | — | WO | disclosed |