Sugi Predict

Sugi Predict / Compounds / SCHEMBL7921128

SCHEMBL7921128

SCHEMBL7921128

Cc1cnc2[nH]cc(C)c2c1

nearest known ligand 0.46

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ MET P08581 1/20 0.46
▸ BTK Q06187 7/20 0.41
▸ ITK Q08881 7/20 0.41
▸ PRMT5 O14744 1/20 0.41
▸ WDR77 Q9BQA1 1/20 0.41
▸ CYP2C19 P33261 3/20 0.39
▸ CYP2C9 P11712 3/20 0.39
▸ CYP3A4 P08684 3/20 0.39
▸ MAP3K12 Q12852 1/20 0.39
▸ AXL P30530 1/20 0.39
▸ PRKCI P41743 1/20 0.39
▸ NOS3 P29474 1/20 0.39
▸ NOS1 P29475 1/20 0.39
▸ NOS2 P35228 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14883424 0.80 JAK2 (0.54) METBTKITKPRMT5WDR77
SCHEMBL1045946 0.80 BRD4 (0.54) ITKCYP2C19CYP2C9CYP3A4AXL
SCHEMBL31228005 0.80 BRD4 (0.54) ITKCYP2C19CYP2C9CYP3A4AXL
SCHEMBL10269012 0.80 MET (0.43) METBTKITKPRMT5WDR77
SCHEMBL13199598 0.80 CYP3A4 (0.44) PRMT5WDR77CYP2C19CYP2C9CYP3A4
SCHEMBL91445 0.80 AXL (0.41) BTKITKPRMT5WDR77CYP2C19
SCHEMBL1566306 0.80 ITK (0.54) METBTKITKPRMT5WDR77
SCHEMBL15154998 0.80 GSK3B (0.56) CYP2C19CYP2C9CYP3A4NOS3NOS1
SCHEMBL21902710 0.80 CYP2C19 (0.40) CYP2C19CYP2C9CYP3A4
SCHEMBL26352450 0.80 CYP3A4 (0.38) CYP2C19CYP2C9CYP3A4AXL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 76 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024039858-A1 ESTROGEN RECEPTOR MODULATORS AND USES THEREOF OLEMA PHARMACEUTICALS, INC. (US) 2024-02-22 — — WO disclosed
US-20230339943-A1 ANTI-INFLUENZA VIRUS PYRIMIDINE DERIVATIVES Guangdong Raynovent Biotech Co., Ltd. (CN) 2023-10-26 — — US disclosed
US-11725009-B2 Anti-influenza virus pyrimidine derivative Guangdong Raynovent Biotech Co., Ltd. (CN) 2023-08-15 — — US disclosed
WO-2023131122-A1 FUSED RING-SUBSTITUTED SIX-MEMBERED HETEROCYCLIC COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF 劲方医药科技(上海)有限公司 2023-07-13 — — WO disclosed
EP-2956138-B1 THERAPEUTIC COMPOUNDS AND USES THEREOF KALA PHARMACEUTICALS INC (US) 2022-06-22 — — EP disclosed
US-20220135558-A1 ANTI-INFLUENZA VIRUS PYRIMIDINE DERIVATIVE Guangdong Raynovent Biotech Co., Ltd. (CN) 2022-05-05 — — US disclosed
EP-3268373-B1 TRICYCLIC DLK INHIBITORS AND USES THEREOF HOFFMANN LA ROCHE (CH) 2022-04-27 — — EP disclosed
WO-2021223736-A1 COMPOUNDS AS BCL-2 INHIBITORS FOCHON PHARMACEUTICALS, LTD. (CN) 2021-11-11 — — WO disclosed
US-11136319-B2 Anti-influenza virus pyrimidine derivative Guangdong Raynovent Biotech Co., Ltd. (CN) 2021-10-05 — — US disclosed
US-20210253571-A1 AZAINDOLE DERIVATIVE AND USE THEREOF AS FGFR AND C-MET INHIBITOR WUXI LIFE FOUNTAIN BIOTECH CO., LTD (CN) 2021-08-19 — — US disclosed
US-7772246-B2 Pyrazole compounds as RAF inhibitors PFIZER INC. (US) 2010-08-10 — — US disclosed
US-7772246-B2 Pyrazole compounds as RAF inhibitors PFIZER INC. (US) 2010-08-10 — — US disclosed
WO-2010050445-A1 BICYCLIC COMPOUND 武田薬品工業株式会社 (JP) 2010-05-06 — — WO disclosed
US-20100003246-A1 Novel heterocyclic compounds and uses therof NOVARTIS AG (CH) 2010-01-07 — — US disclosed
WO-2009157196-A1 AMIDE COMPOUND 武田薬品工業株式会社 (JP) 2009-12-30 — — WO disclosed
US-20090233955-A1 1H-Pyrrolo[2,3-B]Pyridnes GLAXOSMITHKLINE LLC 2009-09-17 — — US disclosed
US-20090221608-A1 PYRAZOLE COMPOUNDS PFIZER INC. 2009-09-03 — — US disclosed
US-20090221608-A1 PYRAZOLE COMPOUNDS PFIZER INC. 2009-09-03 — — US disclosed
WO-2009016460-A2 PYRAZOLE COMPOUNDS AND THEIR USE AS RAF INHIBITORS PFIZER INC. (US) 2009-02-05 — — WO disclosed
US-20080261921-A1 FUSED RING HETEROCYCLE KINASE MODULATORS SGX PHARMACEUTICALS, INC. (US) 2008-10-23 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11725009-B2 Anti-influenza virus pyrimidine derivative ENTPD5, NUDT15, ITPA MET 4720/4885BTK 791/4885ITK 2187/4885
US-20090221608-A1 PYRAZOLE COMPOUNDS BRAF, RAF1, NRAS MET 1051/4885BTK 66/4885ITK 1838/4885
US-20220135558-A1 ANTI-INFLUENZA VIRUS PYRIMIDINE DERIVATIVE ENTPD5, NUDT15, ITPA MET 4720/4885BTK 791/4885ITK 2187/4885
US-20080261921-A1 FUSED RING HETEROCYCLE KINASE MODULATORS MAP3K20, MAP3K19, MAP4K2 MET 578/4885BTK 178/4885ITK 486/4885
US-20210253571-A1 AZAINDOLE DERIVATIVE AND USE THEREOF AS FGFR AND C-MET INHIBITOR MET, FGFR1, FGFR2 MET 1/4885BTK 126/4885ITK 293/4885
US-20230339943-A1 ANTI-INFLUENZA VIRUS PYRIMIDINE DERIVATIVES ENTPD5, NUDT1, ITPA MET 4739/4885BTK 935/4885ITK 2250/4885
US-11136319-B2 Anti-influenza virus pyrimidine derivative ENTPD5, NUDT15, ITPA MET 4720/4885BTK 791/4885ITK 2187/4885
US-20100003246-A1 Novel heterocyclic compounds and uses therof BRAF, ARAF, KRAS MET 384/4885BTK 169/4885ITK 1368/4885
US-20090233955-A1 1H-Pyrrolo[2,3-B]Pyridnes SGK1, SGK2, SGK3 MET 3226/4885BTK 648/4885ITK 349/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.